, Volume 7, Issue 5, pp 296-302

Summaries and recommendations of the global impression method

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摘要

随着临床试验数量的增加, 系统评价越来越多地被用于分析总结跨学科的科研结果。 Meta分析作为一种综合证据的常用方法, 能提供总结大量证据的简捷途径, 但meta 分析不可能适合全部多相性的临床研究, 为此, 就要用一种定性的方法替代它。 总体印象法(Global Impression Method, GIM)作为系统评价中综合多相性临床随机对照试验 (Randomized Controlled Trial, RCT)结果的常用方法, 作者对其研究现状进行了总结。 结果提示, 使用总体印象法和最佳证据合成简化版判定森林图的结果与Meta分析的结果存在中等以上程度的内在及交互一致, 因此, 研究者可用GIM总结RCT结果。 经过正常程序以后, 在决定证据的精确强度时, 个别研究的质量也被考虑, 因此, GIM值得在针灸研究中应用。

Abstract

With the increase in the number of acupuncture clinical trials, systematic reviews are used to summarize key results across many disciplines. Meta-analysis is a popular method for synthesizing evidence as it provides a succinct way of summarizing evidence quantitatively. Due to clinical heterogeneity, however, it is not always possible to use meta-analysis. Instead, a qualitative method is used. The purpose of this paper is to summary the findings of current research on the Global Impression Method (GIM); a method used to synthesize the results of clinically heterogeneous randomized controlled trial (RCT) in systematic reviews. The results indicate that there is moderate to substantial intra-rater and inter-rater agreement when judging the results of the forest plots using a global impression and simplified version of the best evidence synthesis (BES) method when compared to the results of meta-analyses. Thus, the GIM can be used for researchers to synthesize results of RCT. The quality of the individual study can be taken into consideration after this process to determine a more precise strength of the evidence, therefore, GIM worthy to be used in acupuncture or other studies.

Author: Kien Trinh, male, professor, major in acupuncture Cochrane systematic review and sports medicine