Obesity Surgery

, Volume 24, Issue 11, pp 1896–1903

Medication Cost is Significantly Reduced After Roux-en-Y Gastric Bypass in Obese Patients

  • Ina Gesquiere
  • Judith Aron-Wisnewsky
  • Veerle Foulon
  • Steeve Haggege
  • Bart Van der Schueren
  • Patrick Augustijns
  • Jean-Luc Bouillot
  • Karine Clement
  • Arnaud Basdevant
  • Jean-Michel Oppert
  • Marion Buyse
Original Contributions

DOI: 10.1007/s11695-014-1325-8

Cite this article as:
Gesquiere, I., Aron-Wisnewsky, J., Foulon, V. et al. OBES SURG (2014) 24: 1896. doi:10.1007/s11695-014-1325-8

Abstract

Background

This study aims to determine the influence of Roux-en-Y gastric bypass (RYGB) on medication-related costs.

Methods

The study analyzed the types, dosages, and costs of drugs and medical devices prescribed before and after surgery (1, 3, 6, and 12 months and yearly thereafter) in patients who underwent RYGB between June 2004 and May 2010 and had an outpatient visit between December 2009 and May 2010 at Pitié-Salpêtrière University Hospital, Paris, France.

Results

The cohort included 143 patients (78 % female; mean age, 42.9 years; mean BMI, 48.6 kg/m2). Total prescription costs were significantly lower (−32 %, p < 0.001) 1 year after RYGB compared with preoperative costs. However, the cost for medications to prevent RYGB side effects (in particular nutritional deficiencies) displayed a 36-fold increase in the first month postsurgery, but then decreased progressively over time. Importantly, the cost related to the treatment of the two most frequent obesity-related diseases significantly decreased 1 year after surgery. Indeed, prescription costs for treatment of type 2 diabetes (T2D) and obstructive sleep apnea (OSA) (namely CPAP therapy considered as the gold standard treatment) were reduced 1 year after surgery by 85 and by 63 % (both p < 0.001), respectively. We also observed a trend toward a decrease in the prescription costs of other obesity-related diseases, although it did not reach significance in our cohort.

Conclusions

Considering medication to treat both obesity-related diseases and prevention of secondary effects of bariatric surgery, we observed that overall postoperative medication costs were significantly reduced one year after surgery, especially for T2D and OSA.

Keywords

Medication costPrescriptionsObesityComorbiditiesBariatric surgeryRoux-en-Y gastric bypass

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Ina Gesquiere
    • 1
  • Judith Aron-Wisnewsky
    • 2
    • 3
    • 4
  • Veerle Foulon
    • 1
  • Steeve Haggege
    • 5
  • Bart Van der Schueren
    • 6
    • 7
  • Patrick Augustijns
    • 1
  • Jean-Luc Bouillot
    • 8
  • Karine Clement
    • 9
    • 10
    • 11
  • Arnaud Basdevant
    • 9
    • 10
    • 11
  • Jean-Michel Oppert
    • 9
    • 10
  • Marion Buyse
    • 5
    • 12
    • 13
  1. 1.Department of Pharmaceutical and Pharmacological SciencesKU LeuvenLeuvenBelgium
  2. 2.Institute of Cardiometabolism and Nutrition, ICAN, AP-HPPitié-Salpêtrière HospitalParisFrance
  3. 3.Sorbonne Universités, UPMC Univ Paris 06, Nutriomics TeamUMR_S 1166 I, ICANParisFrance
  4. 4.Nutriomics TeamINSERM, UMR_S U1166ParisFrance
  5. 5.Clinical Pharmacy Laboratory, Faculty of PharmacyUniversity Paris XIChatenay-Malabry CedexFrance
  6. 6.Clinical and Experimental EndocrinologyKU LeuvenLeuvenBelgium
  7. 7.Department of EndocrinologyKU Leuven University HospitalsLeuvenBelgium
  8. 8.Visceral Surgery DepartmentAmbroise Paré (AP-HP)Boulogne-BillancourtFrance
  9. 9.Institute of Cardiometabolism and Nutrition, ICAN, AP-HPPitié-Salpêtrière HospitalParisFrance
  10. 10.Sorbonne Universités, UPMC Univ Paris 06, Nutriomics TeamUMR_S 1166 I, ICANParisFrance
  11. 11.Nutriomics TeamINSERM, UMR_S U1166ParisFrance
  12. 12.Pharmacy Department, Saint Antoine Hospital (AP-HP)University Pierre et Marie Curie (UPMC), Paris 6ParisFrance
  13. 13.Institut National de la Santé et de la Recherche Médicale (INSERM), UMRS 938, University Pierre et Marie Curie-(UPMC) Paris 6Centre de recherche de Saint AntoineParisFrance