Obesity Surgery

, Volume 25, Issue 1, pp 7–18

Amelioration of Glycemic Control by Sleeve Gastrectomy and Gastric Bypass in a Lean Animal Model of Type 2 Diabetes: Restoration of Gut Hormone Profile

  • Hans Eickhoff
  • Teresa M. Louro
  • Paulo N. Matafome
  • Filipa Vasconcelos
  • Raquel M. Seiça
  • Francisco Castro e Sousa
Original Contributions

DOI: 10.1007/s11695-014-1309-8

Cite this article as:
Eickhoff, H., Louro, T.M., Matafome, P.N. et al. OBES SURG (2015) 25: 7. doi:10.1007/s11695-014-1309-8

Abstract

Background

In obese diabetic patients, bariatric surgery has been shown to induce remission of type 2 diabetes. Along with weight loss itself, changes in gut hormone profiles after surgery play an important role in the amelioration of glycemic control. However, the potential of gastrointestinal surgery regarding diabetes remission in non-severely obese diabetic patients has yet to be defined. In the present experimental study, we explored the effect of established bariatric procedures with and without duodenal exclusion on glycemic control and gut hormone profile in a lean animal model of type 2 diabetes.

Methods

Forty 12- to 14-week-old non-obese diabetic Goto-Kakizaki (GK) rats were randomly assigned to four groups: control group (GKC), sham surgery (GKSS), sleeve gastrectomy (GKSG), and gastric bypass (GKGB). Age-matched Wistar rats served as a non-diabetic control group (WIC). Glycemic control and plasma lipids were assessed at the beginning of the observation period and 4 weeks after surgery. Fasting and mixed meal-induced plasma levels of ghrelin, glucagon-like peptide-17-36 (GLP-1), and peptide tyrosine-tyrosine (PYY) were measured.

Results

In GK rats, glycemic control improved after sleeve gastrectomy (SG) and gastric bypass (GB). Mixed meal-induced gut hormone profiles in Wistar rats (WIC) were significantly different from those of sham-operated or control group GK rats. After SG and GB, GK rats showed a similar postprandial decrease in ghrelin as observed in non-diabetic WIC. Following both surgical procedures, a significant meal-induced increase in PYY and GLP-1 could be demonstrated.

Conclusions

SG and GB induce a similar improvement in overall glycemic control in lean diabetic rodents. Meal-induced profiles of ghrelin, GLP-1, and PYY in GK rats are significantly modified by SG and GB and become similar to those of non-diabetic Wistar rats. Our data do not support the hypothesis that duodenal exclusion and early contact of food with the ileal mucosa alone explain changes in gut hormone profile in GK rats after gastrointestinal surgery.

Keywords

Metabolic surgery Diabetes surgery Gastric bypass Sleeve Gastrectomy Goto-Kakizaki rats GLP-1 PYY Ghrelin 

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Hans Eickhoff
    • 1
    • 2
  • Teresa M. Louro
    • 2
    • 3
  • Paulo N. Matafome
    • 2
    • 3
  • Filipa Vasconcelos
    • 2
  • Raquel M. Seiça
    • 2
    • 3
  • Francisco Castro e Sousa
    • 4
    • 5
  1. 1.Obesity CenterHospital de SantiagoSetubalPortugal
  2. 2.Institute of Physiology, Faculty of Medicine, Polo IIIUniversity of CoimbraCoimbraPortugal
  3. 3.Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, Polo IIIUniversity of CoimbraCoimbraPortugal
  4. 4.Department of Surgery AUniversity Hospital of CoimbraCoimbraPortugal
  5. 5.Faculty of MedicineUniversity of CoimbraCoimbraPortugal

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