Obesity Surgery

, Volume 24, Issue 11, pp 1881–1887

Impact of Different Criteria on Type 2 Diabetes Remission Rate After Bariatric Surgery

  • A. Mas-Lorenzo
  • D. Benaiges
  • J. A. Flores-Le-Roux
  • J. Pedro-Botet
  • J. M. Ramon
  • A. Parri
  • M. Villatoro
  • J. Chillarón
  • M. Pera
  • L. Grande
  • A. Goday
  • On Behalf of the Obemar Group
Original Contributions

DOI: 10.1007/s11695-014-1282-2

Cite this article as:
Mas-Lorenzo, A., Benaiges, D., Flores-Le-Roux, J.A. et al. OBES SURG (2014) 24: 1881. doi:10.1007/s11695-014-1282-2

Abstract

Background

Laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux-en-Y gastric bypass (LRYGB) achieve similar type 2 diabetes mellitus (T2DM) remission rates. Since a great variability exists in defining T2DM remission, an expert panel proposed partial and complete remission criteria that include the maintenance of fasting plasma glucose (FPG) and glycosylated hemoglobin (A1c) objectives for at least 1 year. The 2-year T2DM remission rate and time needed to reach it after LSG or LRYGB were compared using different remission criteria.

Methods

This was a prospective cohort study of 55 T2DM subjects operated on with LSG (n = 21) or LRYGB (n = 34). Four models for defining remission were used: Buchwald criteria (FPG <100 mg/dl or A1c <6 %), American Diabetes Association (ADA) complete (FPG <100 mg/dl plus A1c <6 % maintained for at least 1 year), ADA partial (FPG <125 mg/dl with A1c <6.5 % maintained for at least 1 year), and ADA complete without time requirement.

Results

Both groups were comparable, except for higher A1c levels in the LSG group. The remission rate ranged from 43.6 % using ADA complete remission to 92.7 % with Buchwald criteria, with no differences between surgical procedures. Differences were found in the time to achieve remission only when ADA complete remission criteria (5.1 ± 2.9 months LRYGB and 9.0 ± 3.8 months LSG, p = 0.014) and ADA without time requirement criteria (4.9 ± 2.7 months LRYGB and 8.4 ± 3.9 months LSG, p = 0.005) were used.

Conclusions

T2DM remission rate varies widely depending on the criteria used for its definition. Remission occurred sooner after LRYGB when the strictest criteria to define remission were used.

Keywords

Severe obesityLaparoscopic sleeve gastrectomyLaparoscopic Roux-en-Y gastric bypassType 2 diabetes mellitus remission

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • A. Mas-Lorenzo
    • 1
  • D. Benaiges
    • 1
    • 2
    • 5
  • J. A. Flores-Le-Roux
    • 1
    • 2
    • 5
  • J. Pedro-Botet
    • 1
    • 2
  • J. M. Ramon
    • 3
  • A. Parri
    • 1
  • M. Villatoro
    • 1
  • J. Chillarón
    • 1
    • 2
    • 5
  • M. Pera
    • 2
    • 3
  • L. Grande
    • 2
    • 3
  • A. Goday
    • 1
    • 2
    • 4
    • 5
  • On Behalf of the Obemar Group
  1. 1.Department of Endocrinology and NutritionHospital del MarBarcelonaSpain
  2. 2.Universitat Autònoma de BarcelonaBarcelonaSpain
  3. 3.Unit of Gastrointestinal SurgeryHospital del MarBarcelonaSpain
  4. 4.CIBEROBNMadridSpain
  5. 5.Institut Hospital del Mar d’Investigacions Mèdiques (IMIM)BarcelonaSpain