Notes on “Roux en Y Gastric Bypass Increases Ethanol Intake in the Rat” by Davis et al.
We read with great interest the article “Roux en Y Gastric Bypass Increases Ethanol Intake in the Rat”  from Jon Davis and colleagues, published online in the Obesity Surgery on February 26, 2013. This study reports an impressive data set showing increased alcohol consumption in an outbred rat strain after Roux-en-Y gastric bypass surgery (RYGB), a finding that has potential important clinical implications. This study supports recent clinical investigations showing increased susceptibility to alcohol abuse following RYGB [2–5] and corroborates our recent studies that reported increased alcohol taking and increased motivation to work for alcohol reward in dietary obese rats that received RYGB [6, 7].
However, we were surprised that the authors did not refer to prior publications showing similar outcomes [6, 7], which would have strengthen the conclusion of their paper. The authors also failed to cite their prior paper , which reported decreases in alcohol intake after RYGB in alcoh ...
- Davis JF, et al. Roux en Y gastric bypass increases ethanol intake in the rat. Obes Surg. 2013. doi:10.1007/s11695-013-0884-4
- Ertelt TW et al. Alcohol abuse and dependence before and after bariatric surgery: a review of the literature and report of a new data set. Surg Obes Relat Dis. 2008;4(5):647–50. CrossRef
- Hsu LK et al. Nonsurgical factors that influence the outcome of bariatric surgery: a review. Psychosom Med. 1998;60(3):338–46.
- Saules KK et al. Bariatric surgery history among substance abuse treatment patients: prevalence and associated features. Surg Obes Relat Dis. 2010;6(6):615–21. CrossRef
- King WC et al. Prevalence of alcohol use disorders before and after bariatric surgery. JAMA. 2012;307(23):2516–25.
- Hajnal A et al. Alcohol reward is increased after Roux-en-Y gastric bypass in dietary obese rats with differential effects following ghrelin antagonism. PLoS One. 2012;7(11):e49121. CrossRef
- Thanos PK et al. Gastric bypass increases ethanol and water consumption in diet-induced obese rats. Obes Surg. 2012;22(12):1884–92. CrossRef
- Davis JF et al. Gastric bypass surgery attenuates ethanol consumption in ethanol-preferring rats. Biol Psychiatry. 2012;72(5):354–60. CrossRef
- Prinz F, Schlange T, Asadullah K. Believe it or not: how much can we rely on published data on potential drug targets? Nat Rev Drug Discov. 2011;10(9):712. CrossRef
- Notes on “Roux en Y Gastric Bypass Increases Ethanol Intake in the Rat” by Davis et al.
Volume 23, Issue 8 , p 1317
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- 1. Department of Neural and Behavioral Sciences, College of Medicine, The Pennsylvania State University, 500 University Drive, Mail code: H181, Hershey, PA, 17033, USA
- 2. Department of Surgery, The Pennsylvania State University College of Medicine, Hershey, PA, USA
- 3. Laboratory of Neuroimaging, NIAAA Intramural Program, NIH, Bethesda, MD, USA
- 4. Behavioral Neuropharmacology and Neuroimaging Lab, Brookhaven National Laboratory, Upton, NY, USA