Roux en Y Gastric Bypass Increases Ethanol Intake in the Rat
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Roux en Y gastric bypass (RYGB) surgery is currently the most effective therapy employed to treat obesity and its associated complications. In addition to weight loss and resolution of metabolic syndromes, such as diabetes, the RYGB procedure has been reported to increase alcohol consumption in humans. Using an outbred rodent model, we demonstrate that RYGB increases postsurgical ethanol consumption, that this effect cannot be explained solely by postsurgical weight loss and that it is independent of presurgical body weight or dietary composition. Altered ethanol metabolism and postsurgical shifts in release of ghrelin were also unable to account for changes in alcohol intake. Further investigation of the potential physiological factors underlying this behavioral effect identified altered patterns of gene expression in brain regions associated with reward following RYGB surgery. These findings have important clinical implications as they demonstrate that RYGB surgery leads directly to increased alcohol intake in otherwise alcohol nonpreferring rat and induces neurobiological changes in brain circuits that mediate a variety of appetitive behaviors.
- Orci L, Chilcott M, Huber O. Short versus long Roux-limb length in Roux en gastric bypass surgery for the treatment of morbid and super obesity: a systematic review of the literature. Obes Surg. 2011;21(6):797–804. CrossRef
- Ertelt TW, Mitchell JE, et al. Alcohol abuse and dependence before and after bariatric surgery: a review of the literature and report of a new data set. Surg Obes Relat Dis. 2008;4(5):647–50. CrossRef
- Kalarchian MA, Marcus MD, et al. Psychiatric disorders among bariatric surgery candidates: relationship to obesity and functional health status. Am J Psychiatry. 2007;164(2):328–34. quiz 374. CrossRef
- Carr KD. Augmenting of drug reward by chronic food restriction: behavioral evidence and underlying mechanisms. Physiol Behav. 2002;76(3):353–64. CrossRef
- Engleman EA, Ding ZM, et al. Ethanol is self-administered into the nucleus accumbens shell, but not the core: evidence of genetic sensitivity. Alcohol Clin Exp Res. 2009;33(12):2162–71. CrossRef
- Lawrence AJ, Cowen MS, et al. The orexin system regulates alcohol-seeking in rats. Br J Pharmacol. 2006;148(6):752–9. CrossRef
- Dunn JP, Cowan RL, et al. Decreased dopamine type 2 receptor availability after bariatric surgery: preliminary findings. Brain Res. 2010;1350:123–30. CrossRef
- Volkow N, Wang GJ, Telang F, et al. Profound decreases in dopamine release in striatum in detoxified alcoholics: possible orbitofrontal involvement. J Neurosci. 2007;27(46):12700–6. CrossRef
- Cummings DE, Weigle DS, et al. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med. 2002;346(21):1623–30. CrossRef
- Shin AC, Zheng H, Townsend RL, et al. Meal-induced hormone responses in a rat model of Roux en Y gastric bypass surgery. Endocrinology. 2010;151(4):1588–97. CrossRef
- Dickson SL, Egecioglu E, Landgren S, et al. The role of the central ghrelin system in reward from food and chemical drugs. Mol Cell Endocrinol. 2011;340(1):80–7. CrossRef
- Jerlhag E, Egecioglu E, et al. Requirement of central ghrelin signaling for alcohol reward. Proc Natl Acad Sci U S A. 2009;106(27):11318–23. CrossRef
- Suzuki J, Haimovici F, Chang G. Alcohol use disorders after bariatric surgery. Obes Surge. 2012;22(2):201–7. CrossRef
- Wang GJ, Volkow ND, Logan J, et al. Brain dopamine and obesity. Lancet. 2001;357(9253):354–7. CrossRef
- Zheng H, Shin AC, et al. Meal patterns, satiety, and food choice in a rat model of Roux-en-Y gastric bypass surgery. Am J Physiol Regul Integr Comp Physiol. 2009;297(5):R1273–82. CrossRef
- Carroll ME, France CP, Meisch RA. Food deprivation increases oral and intravenous drug intake in rats. Science. 1979;20(205):319–21. CrossRef
- Klockhoff H, Naslund I, et al. Faster absorption of ethanol and higher peak concentration in women after gastric bypass surgery. Br J Clin Pharmacol. 2002;54(6):587–91. CrossRef
- Woodward GA, Downey J, Hernandez-Boussard T, et al. Impaired alcohol metabolism after gastric bypass surgery: a case-cross over trial. J Am Coll Surg. 2011;212(2):209–14. CrossRef
- Korner J, Inabnet W, Febres G, et al. Prospective study of gut hormone and metabolic changes after adjustable gastric banding and Roux en Y gastric bypass. Int J Obes. 2009;33(7):786–95. CrossRef
- Martins C, Kjelstrup L, Mostad IL, et al. Impact of sustained weight loss achieved through Roux en Y gastric bypass or a lifestyle intervention on ghrelin, obestatin and ghrelin/obestatin ratio in morbidly obese patients. Obes Surg. 2011;21(6):751–8. CrossRef
- Boileau I, Assaad J-M, et al. Alcohol promotes dopamine release in the human nucleus accumbens. Synapse. 2003;49(4):226–31. CrossRef
- Koob GF, Roberts AJ, Schulteis G, et al. Neurocircuitry targets in ethanol reward and dependence. Alcohol Clin Exp Res. 1998;22:3–9. CrossRef
- Thanos PK, Taintor NB, et al. DRD2 gene transfer into the nucleus accumbens core of the alcohol preferring and nonpreferring rats attenuates alcohol drinking. Alcohol Clin Exp Res. 2004;28(5):720–8. CrossRef
- Narita M, Nagumo Y, et al. Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine. J Neurosci. 2006;26(2):398–405. CrossRef
- Cabeza de Vaca S, Carr KD. Food restriction enhances the central rewarding effects of abused drugs. J Neurosci. 1998;18(18):7502–10.
- Tschoep ML, Smiley DL, Heiman M. Ghrelin induces adiposity in rodents. Nature. 2000;407(6806):908–13. CrossRef
- Barazzoni R, Zanetti M, Nagliati C, et al. Gastric bypass does not normalize obesity-related changes in ghrelin profile and leads to higher acylated ghrelin fraction. Obesity. 2012. doi:10.1038/oby.2012.149.
- Chambers AP, Kirchner H, Wilson-Perez HE, et al. The effects of vertical sleeve gastrectomy in rodents are ghrelin independent. Gastroenterology. 2013. doi:10.1053/j.gastro.2012.09.009.
- Kurose T, Ueta Y, Yamamoto Y, et al. Effects of restricted feeding on the activity of hypothalamic orexin (OX)-A containing neurons and OX2 receptor mRNA in the paraventricular nucleus of rats. Regul Pept. 2002;104(1–3):141–5.
- Schneider ER, Rada P, Darby RD, et al. Orexigenic peptides and alcohol intake: differential effects of orexin, galanin and ghrelin. Alcohol Clin Exp Res. 2007;31(11):1858–65. CrossRef
- Jupp B, Krstew E, Dezsi G, et al. Discrete cue-conditioned alcohol seeking after protracted abstinence: pattern of neuronal activation and involvement of orexin R1 receptors. Br J Pharmacol. 2011;162(4):880–9. CrossRef
- Aston-Jones G, Smith RJ, Sartor GC, et al. Lateral hypothalamic orexin/hypocretin neurons: a role in reward-seeking and addiction. Brain Res. 2010;1341C:74. CrossRef
- Voorhees CM, Cunningham CL. Involvement of the orexin/hypocretin system in ethanol conditioned place preference. Psychopharmacol. 2011;214(4):805–18. CrossRef
- Schoblock JR, Welty N, Alusio L, et al. Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference and reinstatement. Psychopharmacol. 2011;215(1):191–203. CrossRef
- Steele KE, Prokopowicz GP, et al. Alterations of central dopamine receptors before and after gastric bypass surgery. Obes Surg. 2010;20(3):369–74. CrossRef
- Fadel J, Deutch AY. Anatomical substrates of orexin-dopamine interactions: lateral hypothalamic projections to the ventral tegmental area. Neuroscience. 2002;111:379–87. CrossRef
- Volkow ND, Wang GJ, Fowler JS, et al. Prediction of reinforcing responses to psychostimulants in humans by brain dopamine D2 receptor levels. Am J Psychiatry. 1999;156(9):1440–3.
- Heinz A, Siessmeier T, Wrase J, et al. Correlation between dopamine D(2) receptors in the ventral striatum and central processing of alcohol cues and craving. Am J Psychiatry. 2004;161(10):1783–9. CrossRef
- Bulwa ZB, Sharlin JA, Clark PJ, et al. Increased consumption of ethanol and sugar water in mice lacking the dopamine D2 long receptor. Alcohol. 2011;45(7):631–9. CrossRef
- Volkow ND, Wang GJ, Maynard L, et al. Effects of alcohol detoxification on dopamine D2 receptors in alcoholics: a preliminary study. Psychiatry Res. 2002;116(3):163–72. CrossRef
- Volkow N, Wang GJ, Begleiter H, et al. High levels of dopamine D2 receptors in unaffected members of alcoholic families: possible protective factors. Arch Gen Psychiatry. 2006;63(9):999–1008. CrossRef
- Volkow ND, Wang GJ, Fowler JS, et al. Overlapping neuronal circuits in addiction and obesity: evidence of systems pathaology. Phils Trans R Soc Lond B Biol Sci. 2008;363(1507):3191–200. CrossRef
- Hajnal A, Norgren R. Repeated access to sucrose augments dopamine turnover in the nucleus accumbens. Neuroreport. 2002;13:2213–6. doi:10.1097/00001756-200212030-00010. CrossRef
- Park TH, Carr KD. Neuroanatomical pattern of fos-like immunoreactivity induced by a palatable meal and meal-paired environment in saline- and naltrexone-treated rats. Brain Res. 1998;805(1–2):169–80. CrossRef
- Geiger BM, Haburcak M, Avena NM, et al. Deficits of mesolimbic dopamine transmission in rat dietary obesity. Neuroscience. 2009;159(4):1193–9. CrossRef
- Rada P, Bocarsly ME, Barson JR, et al. Reduced accumbens dopamine in Sprague–Dawley rats prone to overeating a fat-rich diet. Physiol Behav. 2009;101(3):394–400. CrossRef
- Bello EP, Mateo Y, Gelman DM, et al. Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors. Nat Neurosci. 2011;14(8):1033–8. CrossRef
- Wiederman MW, Pryor T. Substance use among women with eating disorders. Int J Eat Disord. 1996;20:163–8. doi:10.1002/(SICI)1098-108X(199609)20:2_163::AID-EAT6_3.0.CO;2-E. CrossRef
- Puhl M, Cason A, Wojnicki F, et al. A history of bingeing on fat enhances cocaine seeking and taking. Behav Neurosci. 2011;125(6):930–42. CrossRef
- Bocchieri LE, Meana M, Fisher BL. A review of psychosocial outcomes of surgery for morbid obesity. J Psychosom Res. 2002;52(3):155–65. CrossRef
- Herpertz S, Kielmann R, Wolf A, et al. Does obesity surgery improve psychosocial functioning? A systematic review. Int J Obesity. 2003;27(11):1300–14. CrossRef
- van Hout GC, Boekestein P, Fortuin FA, et al. Psychosocial functioning following bariatric surgery. Obes Surg. 2006;16(6):787–94. CrossRef
- Sarwer D, Fabricatore A, Jones-Corneille L, et al. Psychological issues following bariatric surgery. Primary Psychiatry. 2008;8:50–5.
- Abbey A, Smith M. Psychosocial factors that influence American adults alcohol consumption. Drug Alcohol Abuse Rev. 1992;3:1–31.
- Koob GF, Sanna P, Bloom F. Neuroscience of addiction. Neuron. 1998;21:467–76. CrossRef
- Lawrence AJ. Regulation of alcohol-seeking by orexin (hypocretin) neurons. Brain Res. 2010;1314:124–9. CrossRef
- Hodge CW, Samson HH, Chappelle AM. Alcohol self-administration: further examination of the role of dopamine receptors in the nucleus accumbens. Alcohol Clin Exp Res. 1997;21:1083–91.
- Roux en Y Gastric Bypass Increases Ethanol Intake in the Rat
Volume 23, Issue 7 , pp 920-930
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- 1. Department of Psychiatry and Behavioral Neuroscience, Metabolic Diseases Institute, University of Cincinnati, Cincinnati, OH, USA
- 4. Metabolic Diseases Institute, University of Cincinnati, Room 234, Cincinnati, OH, 45237-506, USA
- 3. Department of Psychology, Grinnell College, Grinnell, IA, USA
- 2. Department of Internal Medicine, Metabolic Diseases Institute, University of Cincinnati, Cincinnati, OH, USA