Obesity Surgery

, Volume 23, Issue 6, pp 819–825

Influence of Bariatric Surgery on the Use and Pharmacokinetics of Some Major Drug Classes

  • Jan Peter Yska
  • Susanne van der Linde
  • Véronique V. Tapper
  • Jan A. Apers
  • Marloes Emous
  • Erik R. Totté
  • Bob Wilffert
  • Eric N. van Roon
Review

DOI: 10.1007/s11695-013-0882-6

Cite this article as:
Yska, J.P., van der Linde, S., Tapper, V.V. et al. OBES SURG (2013) 23: 819. doi:10.1007/s11695-013-0882-6

Abstract

The purpose of this review is to evaluate the influence of bariatric surgery on the use and pharmacokinetics of some frequently used drugs. A PubMed literature search was conducted. Literature was included on influence of bariatric surgery on pharmacoepidemiology and pharmacokinetics. Drug classes to be searched for were antidepressants, antidiabetics, statins, antihypertensive agents, corticosteroids, oral contraceptives, and thyroid drugs. A reduction in the use of medication by patients after bariatric surgery has been reported for various drug classes. Very few studies have been published on the influence of bariatric surgery on the pharmacokinetics of drugs. After bariatric surgery, theoretically, reduced drug absorption may occur. Correct dosing and choosing the right dosage form for drugs used by patients after bariatric surgery are necessary for optimal pharmacotherapy. Therefore, more clinical studies are needed on the influence of bariatric surgery on the pharmacokinetics of major drugs.

Keywords

Bariatric surgeryPharmacoepidemiologyPharmacokineticsDrug class

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Jan Peter Yska
    • 1
  • Susanne van der Linde
    • 1
  • Véronique V. Tapper
    • 1
  • Jan A. Apers
    • 2
  • Marloes Emous
    • 2
  • Erik R. Totté
    • 2
  • Bob Wilffert
    • 3
    • 4
  • Eric N. van Roon
    • 1
  1. 1.Department of Clinical Pharmacy and Clinical PharmacologyMedisch Centrum LeeuwardenLeeuwardenThe Netherlands
  2. 2.Department of SurgeryMedisch Centrum LeeuwardenLeeuwardenThe Netherlands
  3. 3.Unit of Pharmacotherapy and Pharmaceutical Care, Department of PharmacyUniversity of GroningenGroningenThe Netherlands
  4. 4.Department of Hospital and Clinical Pharmacy, University Medical Center GroningenUniversity of GroningenGroningenThe Netherlands