Improvement of Atherosclerotic Markers in Non-diabetic Patients After Bariatric Surgery
- Mohamed Hassan Saleh,
- Marcelo Chiara Bertolami,
- Jorge Eduardo Assef,
- Mohamed Ibrahim Taha,
- Wilson de Freitas Jr.,
- Ana Claudia Gomes Petisco,
- Rodrigo Bellio Mattos Barretto,
- David Costa Le Bihan,
- Jose Eduardo Martins Barbosa,
- Carlos Alberto de Jesus,
- Amanda Guerra Moraes Rego Sousa
- … show all 11 hide
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The objective of this study was to assess the impact of bariatric surgery performed in extremely obese non-diabetic subjects on the following parameters: endothelial function, inflammatory processes (assessed by high-sensitivity C-reactive protein [hs-CRP]), carotid artery intima-media thickness (CIMT), and glucose and lipid profiles.
Forty-seven obese individuals with body mass index >40 kg/m2 underwent bariatric surgery and returned for post-procedure assessment between 6 and 19 months after surgery. Ninety-three percent of patients were female. Their age ranged from 18 to 65 (mean 41) years old at baseline. Baseline was defined as the maximum of 30 days before surgery. Before and after surgery, all patients were subjected to a brachial artery ultrasound examination to evaluate endothelial-dependent dilation, CIMT by ultrasound, and laboratory analyses including glucose, lipid and inflammatory profiles were performed.
Subjects lost an average of 33 % of their original weight (p < 0.001). Flow-mediated dilation showed significant improvement after surgery from 7.4 % to 18.9 % (p < 0.001) on average. There was regression of CIMT, with the median being reduced from 0.8 to 0.5 mm (p < 0.001). The median Hs-CRP reduced from 0.83 to 0.18 mg/dl (p < 0.001), while glucose and lipid profiles were also improved after surgery.
This study shows that severely obese, non-diabetic patients who had pronounced weight loss after bariatric surgery had an overall improvement in brachial flow-mediated dilation, CIMT, high-sensitivity CRP, and glucose and lipid metabolism. The best responses of the brachial flow-mediated dilation after surgery were observed in non-smokers and in younger subjects.
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About this Article
- Improvement of Atherosclerotic Markers in Non-diabetic Patients After Bariatric Surgery
Volume 22, Issue 11 , pp 1701-1707
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- Carotid arteries
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- Mohamed Hassan Saleh (1) (3)
- Marcelo Chiara Bertolami (1)
- Jorge Eduardo Assef (1)
- Mohamed Ibrahim Taha (2)
- Wilson de Freitas Jr. (2)
- Ana Claudia Gomes Petisco (1)
- Rodrigo Bellio Mattos Barretto (1)
- David Costa Le Bihan (1)
- Jose Eduardo Martins Barbosa (1)
- Carlos Alberto de Jesus (1)
- Amanda Guerra Moraes Rego Sousa (1)
- Author Affiliations
- 1. Instituto Dante Pazzanese de Cardiologia, State of Sao Paulo – Health Secretary, Sao Paulo, Brazil
- 3. Rua Dona Januaria 125, Apartment 112, Vila Regente Feijo, Sao Paulo, SP, 03336-055, Brazil
- 2. Santa Casa de Misericordia de Sao Paulo, Sao Paulo, Brazil