Obesity Surgery

, Volume 22, Issue 9, pp 1481–1490

Short-Term Effects of Sleeve Gastrectomy and Caloric Restriction on Blood Pressure in Diet-Induced Obese Rats

Authors

  • Amaia Rodríguez
    • Metabolic Research LaboratoryClínica Universidad de Navarra
    • CIBER Fisiopatología de la Obesidad y NutriciónInstituto de Salud Carlos III
  • Sara Becerril
    • Metabolic Research LaboratoryClínica Universidad de Navarra
    • CIBER Fisiopatología de la Obesidad y NutriciónInstituto de Salud Carlos III
  • Víctor Valentí
    • Department of SurgeryClínica Universidad de Navarra
    • CIBER Fisiopatología de la Obesidad y NutriciónInstituto de Salud Carlos III
  • Rafael Moncada
    • Department of AnesthesiaClínica Universidad de Navarra
  • Leire Méndez-Giménez
    • Metabolic Research LaboratoryClínica Universidad de Navarra
  • Beatriz Ramírez
    • Metabolic Research LaboratoryClínica Universidad de Navarra
    • CIBER Fisiopatología de la Obesidad y NutriciónInstituto de Salud Carlos III
  • Andoni Lancha
    • Metabolic Research LaboratoryClínica Universidad de Navarra
  • Marina Martín
    • Department of Histology and PathologyUniversity of Navarra
  • María A. Burrell
    • Department of Histology and PathologyUniversity of Navarra
    • CIBER Fisiopatología de la Obesidad y NutriciónInstituto de Salud Carlos III
  • Victoria Catalán
    • Metabolic Research LaboratoryClínica Universidad de Navarra
    • CIBER Fisiopatología de la Obesidad y NutriciónInstituto de Salud Carlos III
  • Javier Gómez-Ambrosi
    • Metabolic Research LaboratoryClínica Universidad de Navarra
    • CIBER Fisiopatología de la Obesidad y NutriciónInstituto de Salud Carlos III
    • Metabolic Research LaboratoryClínica Universidad de Navarra
    • Department of Endocrinology and NutritionClínica Universidad de Navarra
    • CIBER Fisiopatología de la Obesidad y NutriciónInstituto de Salud Carlos III
Animal Research

DOI: 10.1007/s11695-012-0702-4

Cite this article as:
Rodríguez, A., Becerril, S., Valentí, V. et al. OBES SURG (2012) 22: 1481. doi:10.1007/s11695-012-0702-4

Abstract

Background

Sleeve gastrectomy constitutes an effective surgical procedure for the treatment of morbid obesity. The aim of the present study was to establish the effects of sleeve gastrectomy and caloric restriction on weight loss and cardiovascular parameters in diet-induced obese (DIO) rats.

Methods

Male Wistar DIO rats were subjected to surgical interventions (n = 30) (sham operation, sleeve gastrectomy, or pair-fed to the amount of food eaten by sleeve-gastrectomized animals and compared to lean control rats) or dietary interventions (n = 40) (fed ad libitum a normal diet (ND) or a high-fat diet or an ND with a caloric restriction of 25 %). Systolic blood pressure (SBP), diastolic blood pressure, and mean blood pressure values and heart rate (HR) were recorded in conscious, resting animals by noninvasive tail-cuff plethysmography before and 3 weeks after surgical or dietary interventions.

Results

Both sleeve gastrectomy and caloric restriction induced a reduction in body weight, whole-body adiposity, and serum leptin together with an increased excess weight loss in DIO rats. Sleeve gastrectomy was further associated with an improvement in insulin resistance and the lipid profile, as well as with a reduction in serum ghrelin levels. A decrease in HR and heart weight was observed in caloric-restricted groups. Sleeve-gastrectomized rats not only exhibited a reduction in HR (∆HR = −45 ± 19 bpm) but also in SBP values (∆SBP = −22 ± 10 mmHg) compared to the DIO rats (∆SBP = 14 ± 8 mmHg).

Conclusion

Our findings provide evidence that the beneficial effects of sleeve gastrectomy on blood pressure values are beyond weight loss in rats with diet-induced obesity.

Keywords

Experimental models of bariatric surgerySleeve gastrectomyCaloric restrictionBlood pressureDiet-induced obesity

Abbreviations

CVD

Cardiovascular disease

DBP

Diastolic blood pressure

EWL

Excess weight loss

HR

Heart rate

MBP

Mean blood pressure

SBP

Systolic blood pressure

Copyright information

© Springer Science + Business Media, LLC 2012