Duodenal–Jejunal Bypass Surgery Does Not Increase Skeletal Muscle Insulin Signal Transduction or Glucose Disposal in Goto–Kakizaki Type 2 Diabetic Rats
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Duodenal–jejunal bypass (DJB) has been shown to reverse type 2 diabetes (T2DM) in Goto–Kakizaki (GK) rats, a rodent model of non-obese T2DM. Skeletal muscle insulin resistance is a hallmark decrement in T2DM. The aim of the current work was to investigate the effects of DJB on skeletal muscle insulin signal transduction and glucose disposal. It was hypothesized that DJB would increase skeletal muscle insulin signal transduction and glucose disposal in GK rats.
DJB was performed in GK rats. Sham operations were performed in GK and nondiabetic Wistar–Kyoto (WKY) rats. At 2 weeks post-DJB, oral glucose tolerance (OGTT) was measured. At 3 weeks post-DJB, insulin-induced signal transduction and glucose disposal were measured in skeletal muscle.
In GK rats and compared to sham operation, DJB did not (1) improve fasting glucose or insulin, (2) improve OGTT, or (3) increase skeletal muscle insulin signal transduction or glucose disposal. Interestingly, skeletal muscle glucose disposal was similar between WKY-Sham, GK-Sham, and GK-DJB.
Bypassing of the proximal small intestine does not increase skeletal muscle glucose disposal. The lack of skeletal muscle insulin resistance in GK rats questions whether this animal model is adequate to investigate the etiology and treatments for T2DM. Additionally, bypassing of the foregut may lead to different findings in other animal models of T2DM as well as in T2DM patients.
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- Duodenal–Jejunal Bypass Surgery Does Not Increase Skeletal Muscle Insulin Signal Transduction or Glucose Disposal in Goto–Kakizaki Type 2 Diabetic Rats
Volume 21, Issue 2 , pp 231-237
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Type 2 diabetes
- Duodenal–jejunal bypass
- Skeletal muscle glucose disposal
- Industry Sectors
- Timothy P. Gavin (1) (2) (3) (5)
- Ruben C. Sloan III (1) (2)
- Eric Z. Lukosius (1) (2)
- Melissa A. Reed (1) (2)
- John R. Pender (4)
- Van Boghossian (4)
- Jacqueline J. Carter (4)
- Robert D. McKernie (1) (2) (3)
- Kushal Parikh (1) (2) (3)
- J. William Price (3)
- Edward B. Tapscott (3)
- Walter J. Pories (4)
- G. Lynis Dohm (3)
- Author Affiliations
- 1. Human Performance Laboratory, East Carolina University, 363 Ward Sports Medicine Bldg., Greenville, NC, 27858, USA
- 2. Department of Exercise and Sport Science, East Carolina University, Greenville, NC, 27858, USA
- 3. Department of Physiology, East Carolina University, Greenville, NC, 27858, USA
- 5. East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC, 27858, USA
- 4. Department of Surgery, East Carolina University, Greenville, NC, 27858, USA