Obesity Surgery

, Volume 21, Issue 2, pp 231–237

Duodenal–Jejunal Bypass Surgery Does Not Increase Skeletal Muscle Insulin Signal Transduction or Glucose Disposal in Goto–Kakizaki Type 2 Diabetic Rats

Authors

    • Human Performance LaboratoryEast Carolina University
    • Department of Exercise and Sport ScienceEast Carolina University
    • Department of PhysiologyEast Carolina University
    • East Carolina Diabetes and Obesity InstituteEast Carolina University
  • Ruben C. SloanIII
    • Human Performance LaboratoryEast Carolina University
    • Department of Exercise and Sport ScienceEast Carolina University
  • Eric Z. Lukosius
    • Human Performance LaboratoryEast Carolina University
    • Department of Exercise and Sport ScienceEast Carolina University
  • Melissa A. Reed
    • Human Performance LaboratoryEast Carolina University
    • Department of Exercise and Sport ScienceEast Carolina University
  • John R. Pender
    • Department of SurgeryEast Carolina University
  • Van Boghossian
    • Department of SurgeryEast Carolina University
  • Jacqueline J. Carter
    • Department of SurgeryEast Carolina University
  • Robert D. McKernie
    • Human Performance LaboratoryEast Carolina University
    • Department of Exercise and Sport ScienceEast Carolina University
    • Department of PhysiologyEast Carolina University
  • Kushal Parikh
    • Human Performance LaboratoryEast Carolina University
    • Department of Exercise and Sport ScienceEast Carolina University
    • Department of PhysiologyEast Carolina University
  • J. William Price
    • Department of PhysiologyEast Carolina University
  • Edward B. Tapscott
    • Department of PhysiologyEast Carolina University
  • Walter J. Pories
    • Department of SurgeryEast Carolina University
  • G. Lynis Dohm
    • Department of PhysiologyEast Carolina University
Physiology Research

DOI: 10.1007/s11695-010-0304-y

Cite this article as:
Gavin, T.P., Sloan, R.C., Lukosius, E.Z. et al. OBES SURG (2011) 21: 231. doi:10.1007/s11695-010-0304-y

Abstract

Background

Duodenal–jejunal bypass (DJB) has been shown to reverse type 2 diabetes (T2DM) in Goto–Kakizaki (GK) rats, a rodent model of non-obese T2DM. Skeletal muscle insulin resistance is a hallmark decrement in T2DM. The aim of the current work was to investigate the effects of DJB on skeletal muscle insulin signal transduction and glucose disposal. It was hypothesized that DJB would increase skeletal muscle insulin signal transduction and glucose disposal in GK rats.

Methods

DJB was performed in GK rats. Sham operations were performed in GK and nondiabetic Wistar–Kyoto (WKY) rats. At 2 weeks post-DJB, oral glucose tolerance (OGTT) was measured. At 3 weeks post-DJB, insulin-induced signal transduction and glucose disposal were measured in skeletal muscle.

Results

In GK rats and compared to sham operation, DJB did not (1) improve fasting glucose or insulin, (2) improve OGTT, or (3) increase skeletal muscle insulin signal transduction or glucose disposal. Interestingly, skeletal muscle glucose disposal was similar between WKY-Sham, GK-Sham, and GK-DJB.

Conclusions

Bypassing of the proximal small intestine does not increase skeletal muscle glucose disposal. The lack of skeletal muscle insulin resistance in GK rats questions whether this animal model is adequate to investigate the etiology and treatments for T2DM. Additionally, bypassing of the foregut may lead to different findings in other animal models of T2DM as well as in T2DM patients.

Keywords

Type 2 diabetes Duodenal–jejunal bypass Skeletal muscle glucose disposal

Copyright information

© Springer Science + Business Media, LLC 2010