Obesity Surgery

, Volume 21, Issue 9, pp 1444–1450

Reversible Gastric Restriction Implant: Safety and Efficacy in a Canine Model

  • Xiaomei Guo
  • Hai Zheng
  • Samer G. Mattar
  • Xiao Lu
  • George Sandusky
  • Jose A. Navia
  • Ghassan Kassab
Animal Research

DOI: 10.1007/s11695-010-0299-4

Cite this article as:
Guo, X., Zheng, H., Mattar, S.G. et al. OBES SURG (2011) 21: 1444. doi:10.1007/s11695-010-0299-4

Abstract

Background

Gastric restrictive procedures are considered effective weight loss treatment for severe obesity. The aim of the study was to evaluate the efficacy and safety of a reversible implant that renders a partial restriction of stomach in a canine model.

Methods

The device was comprised of two longitudinal parallel non-compressive plates with two C-rings to create a small gastric pouch that opposed gastric distension. Three groups of non-obese mongrel dogs were included: group I (n = 6) underwent surgical implant for 6 weeks, group II (n = 6) underwent surgical implant for 6 weeks, followed by surgical removal of the implant and additional monitoring for 5 weeks, and group III (n = 5) served as sham-operated controls for groups I and II. Food intake and body weight were monitored, and the stomachs were examined histologically postmortem.

Results

The average food intake was significantly decreased by 38.2% in group I as compared to group III throughout the 6 weeks of surgical implant (P < 0.05). The implanted dogs showed a progressive weight loss as compared to sham, which reached 21% by the end of 6 weeks. In group II, after 5 weeks of implant removal, the body weights recovered to approximately 96% of baseline. Histological evidence of the implant site at the gastric walls revealed no significant structural changes, tissue ischemia, hemorrhage, or necrosis.

Conclusion

Our results validate the feasibility of a reversible gastric restriction implant in a non-obese canine model, with the potential for achieving significant weight loss within 6 weeks and with no injury to the gastric wall.

Keywords

ObesityRestrictive procedureImplantFood intakeBody weight

Copyright information

© Springer Science + Business Media, LLC 2010

Authors and Affiliations

  • Xiaomei Guo
    • 1
  • Hai Zheng
    • 1
  • Samer G. Mattar
    • 2
  • Xiao Lu
    • 1
  • George Sandusky
    • 3
  • Jose A. Navia
    • 4
  • Ghassan Kassab
    • 1
    • 2
    • 5
  1. 1.Department of Biomedical EngineeringIndiana University–Purdue University IndianapolisIndianapolisUSA
  2. 2.Department of SurgeryIUPUIIndianapolisUSA
  3. 3.Department of PathologyIUPUIIndianapolisUSA
  4. 4.Department of SurgeryAustral UniversityBuenos AiresArgentina
  5. 5.Cellular and Integrative PhysiologyIUPUIIndianapolisUSA