Obesity Surgery

, Volume 21, Issue 9, pp 1438–1443

Sleeve Gastrectomy Induces Weight Loss in Diet-Induced Obese Rats Even if High-Fat Feeding Is Continued

  • Víctor Valentí
  • Marina Martín
  • Beatriz Ramírez
  • Javier Gómez-Ambrosi
  • Amaia Rodríguez
  • Victoria Catalán
  • Sara Becerril
  • Andoni Lancha
  • Secundino Fernández
  • Javier A. Cienfuegos
  • María A. Burrell
  • Gema Frühbeck
Animal Research

DOI: 10.1007/s11695-010-0277-x

Cite this article as:
Valentí, V., Martín, M., Ramírez, B. et al. OBES SURG (2011) 21: 1438. doi:10.1007/s11695-010-0277-x

Abstract

Background

Sleeve gastrectomy (SG) has been used for the surgical treatment of morbid obesity as a first or definitive procedure with satisfactory results. The objective of this study in rats was to establish the effects of SG on weight loss depending on the post-surgical type of diet followed.

Methods

Thirty male Wistar rats were fed ad libitum during 3 months on a high-fat diet (HFD) to induce obesity. After this first phase, rats were subdivided in three groups of ten rats each and underwent a sham intervention, an SG, or no surgery but were pair-fed to the amount of food eaten by the animals of the SG group. At this time point, half of the animals in each group continued to be fed on the HFD, while the other half was switched to a normal chow diet (ND). Thus, the following subgroups were established: sham-ND, sleeve-ND, pair-fed-ND as well as sham-HFD, sleeve-HFD, and pair-fed-HFD. Body weight and food intake were recorded daily for 4 weeks. The feed efficiency rate (FER) was determined from weekly weight gains and caloric consumption during this period.

Results

Statistically significant (P < 0.05) differences in body weight were observed between the six experimental groups after 4 weeks of the interventions with rats in the sleeve-ND group experimenting the highest weight loss (−78.2 ± 10.3 g) and animals in the pair-fed-HFD group exhibiting the lowest weight reduction (−4.0 ± 0.1 g). Interestingly, the FER value of rats that underwent the SG and continued to be fed on a HFD was significantly (P < 0.05) lower than that of sham operated and pair-fed animals on the same diet.

Conclusion

The positive effects of SG on weight reduction are observed in obese rats submitted to the intervention and subsequently following an ND or even an HFD.

Keywords

Experimental models of bariatric surgerySleeve gastrectomyFood intake

Abbreviations

SG

Sleeve gastrectomy

HFD

High-fat diet

ND

Normal chow diet

FER

Feed efficiency rate

Copyright information

© Springer Science + Business Media, LLC 2010

Authors and Affiliations

  • Víctor Valentí
    • 1
  • Marina Martín
    • 2
  • Beatriz Ramírez
    • 3
    • 4
  • Javier Gómez-Ambrosi
    • 3
    • 4
  • Amaia Rodríguez
    • 3
    • 4
  • Victoria Catalán
    • 3
    • 4
  • Sara Becerril
    • 3
    • 4
  • Andoni Lancha
    • 3
  • Secundino Fernández
    • 5
  • Javier A. Cienfuegos
    • 1
    • 4
  • María A. Burrell
    • 2
  • Gema Frühbeck
    • 3
    • 4
    • 6
  1. 1.Department of SurgeryClínica Universidad de NavarraPamplonaSpain
  2. 2.Department of Histology and PathologyUniversity of NavarraPamplonaSpain
  3. 3.Metabolic Research LaboratoryUniversity of NavarraPamplonaSpain
  4. 4.CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos IIIUniversity of NavarraPamplonaSpain
  5. 5.Department of OtorhinolaryngologyClínica Universidad de NavarraPamplonaSpain
  6. 6.Department of Endocrinology and Nutrition, Clínica Universidad de NavarraUniversity of NavarraPamplonaSpain