Efficacy of Low-Level Laser Therapy for Body Contouring and Spot Fat Reduction
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Low-level laser therapy (LLLT) is commonly used in medical applications, but scientific studies of its efficacy and the mechanism by which it causes loss of fat from fat cells for body contouring are lacking. This study examined the effectiveness and mechanism by which 635–680 nm LLLT acts as a non-invasive body contouring intervention method.
Forty healthy men and women ages 18–65 years with a BMI <30 kg/m2 were randomized 1:1 to laser or control treatment. Subject's waistlines were treated 30 min twice a week for 4 weeks. Standardized waist circumference measurements and photographs were taken before and after treatments 1, 3, and 8. Subjects were asked not to change their diet or exercise habits. In vitro assays were conducted to determine cell lysis, glycerol, and triglyceride release.
Data were analyzed for those with body weight fluctuations within 1.5 kg during 4 weeks of the study. Each treatment gave a 0.4–0.5 cm loss in waist girth. Cumulative girth loss after 4 weeks was −2.15 cm (−0.78 ± 2.82 vs. 1.35 ± 2.64 cm for the control group, p < 0.05). A blinded evaluation of standardized pictures showed statistically significant cosmetic improvement after 4 weeks of laser treatment. In vitro studies suggested that laser treatment increases fat loss from adipocytes by release of triglycerides, without inducing lipolysis or cell lysis.
LLLT achieved safe and significant girth loss sustained over repeated treatments and cumulative over 4 weeks of eight treatments. The girth loss from the waist gave clinically and statistically significant cosmetic improvement.
- King PR. Low level laser therapy: a review. Lasers Med Sci. 1989;4:141. CrossRef
- Neira R, Arroyave J, Ramirez H, et al. Fat liquefaction: effect of low-level laser energy on adipose tissue. Plast Reconstr Surg. 2002;110:912–22. discussion 923–5. CrossRef
- Benedicenti A, Verrando M, Cherlone F, et al. Effect of a 904 nm laser on microcirculation and arteriovenous circulation as evaluated using telethermographic imaging. Parodontol Stomatol (Nuova). 1984;23:167–78.
- Dortbudak O, Haas R, Mallath-Pokorny G. Biostimulation of bone marrow cells with a diode soft laser. Clin Oral Implants Res. 2000;11:540–5. CrossRef
- Garavello-Freitas I, Baranauskas V, Joazeiro PP, et al. Low-power laser irradiation improves histomorphometrical parameters and bone matrix organization during tibia wound healing in rats. J Photochem Photobiol B. 2003;70:81–9. CrossRef
- Hall G, Anneroth G, Schennings T, et al. Effect of low level energy laser irradiation on wound healing. An experimental study in rats. Swed Dent J. 1994;18:29–34.
- Mester E, Mester AF, Mester A. The biomedical effects of laser application. Lasers Surg Med. 1985;5:31–9. CrossRef
- Campana V, Moya M, Gavotto A, et al. Effects of diclofenac sodium and He:Ne laser irradiation on plasmatic fibrinogen levels in inflammatory processes. J Clin Laser Med Surg. 1998;16:317–20.
- Caruso MK, Pekarovic S, Raum WJ, et al. Topical fat reduction from the waist. Diabetes Obes Metab. 2007;9:300–3. CrossRef
- Bunnell BA, Estes BT, Guilak F, et al. Differentiation of adipose stem cells. Methods Mol Biol. 2008;456:155–71. CrossRef
- Rogers PM, Fusinski KA, Rathod MA, et al. Human adenovirus Ad-36 induces adipogenesis via its E4 orf-1 gene. Int J Obes (Lond). 2008;32:397–406. CrossRef
- Karu T. Photobiological fundamentals of low power laser therapy. IEEE J Quantum Electron. 1987;23:1703–18. CrossRef
- Robinson MF, Watson PE. Day-to-day variations in body-weight of young women. Br J Nutr. 1965;19:225–35. CrossRef
- Gay-Crosier F, Polla LL, Tschopp J, et al. Complement activation by pulsed tunable dye laser in normal skin and hemangioma. J Invest Dermatol. 1990;94:426–31. CrossRef
- Dhami LD, Agarwal M. Safe total corporal contouring with large-volume liposuction for the obese patient. Aesthetic Plast Surg. 2006;30:574–88. CrossRef
- Efficacy of Low-Level Laser Therapy for Body Contouring and Spot Fat Reduction
Volume 21, Issue 6 , pp 722-729
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Cold laser
- Fat reduction
- Low-level laser therapy
- Non-invasive laser
- Industry Sectors
- Author Affiliations
- 1. School of Human Ecology, Louisiana State University, Baton Rouge, LA, 70803, USA
- 2. Plastic and Reconstructive Surgery, Baton Rouge, LA, 70808, USA
- 3. Research Practice Partners, Miramar, FL, 33027, USA
- 4. Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, 70808, USA