Obesity Surgery

, Volume 19, Issue 5, pp 608–616

Lipoprotein Lipase Expression in Livers of Morbidly Obese Patients Could be Responsible for Liver Steatosis

Authors

  • Eva Pardina
    • Biochemistry and Molecular Biology Department, Biology FacultyBarcelona University
  • Juan A. Baena-Fustegueras
    • Institut de Recerca Vall D’HebronUniversitat Autònoma De Barcelona
    • Endocrinology Surgery UnitInstituto de Salud Carlos III (ISCIII)
  • Rafael Llamas
    • Biochemistry and Molecular Biology Department, Biology FacultyBarcelona University
  • Roberto Catalán
    • Institut de Recerca Vall D’HebronUniversitat Autònoma De Barcelona
    • Biochemistry DepartmentInstituto de Salud Carlos III (ISCIII)
  • Rosa Galard
    • Institut de Recerca Vall D’HebronUniversitat Autònoma De Barcelona
    • Biochemistry DepartmentInstituto de Salud Carlos III (ISCIII)
  • Albert Lecube
    • Institut de Recerca Vall D’HebronUniversitat Autònoma De Barcelona
    • Diabetes Research Unit, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)Instituto de Salud Carlos III (ISCIII)
  • Jose M. Fort
    • Institut de Recerca Vall D’HebronUniversitat Autònoma De Barcelona
    • Endocrinology Surgery UnitInstituto de Salud Carlos III (ISCIII)
  • Miquel Llobera
    • Biochemistry and Molecular Biology Department, Biology FacultyBarcelona University
  • Helena Allende
    • Institut de Recerca Vall D’HebronUniversitat Autònoma De Barcelona
    • CIBER de Enfermedades Hepáticas y Digestivas (CIBERHED)Instituto de Salud Carlos III (ISCIII)
  • Víctor Vargas
    • Institut de Recerca Vall D’HebronUniversitat Autònoma De Barcelona
    • CIBER de Enfermedades Hepáticas y Digestivas (CIBERHED)Instituto de Salud Carlos III (ISCIII)
    • Biochemistry and Molecular Biology Department, Biology FacultyBarcelona University
Clinical Research

DOI: 10.1007/s11695-009-9827-5

Cite this article as:
Pardina, E., Baena-Fustegueras, J.A., Llamas, R. et al. OBES SURG (2009) 19: 608. doi:10.1007/s11695-009-9827-5

Abstract

Background

Most patients with morbid obesity develop non-alcoholic fatty liver disease (NAFLD). The origins of lipid deposition in the liver and the effects of bariatric surgery in the obese with NAFLD are controversial.

Methods

We analyzed lipids and lipoprotein lipase (LPL) in both plasma and liver biopsies performed before and 12–18 months after Roux-en-Y gastric bypass surgery in 26 patients.

Results

In the livers of morbidly obese patients, the levels of LPL messenger RNA (mRNA) were higher (4.5-fold) before surgery than afterwards than control livers. In these patients, LPL activity was also significantly higher (91 ± 7 mU/g) than in controls (51 ± 3 mU/g, p = 0.0026) and correlated with the severity of the liver damage. All hepatic lipids were significantly increased in obese patients; however, after bariatric surgery, these lipids, with the exception of NEFA, tended to recover to normal levels.

Conclusions

The liver of obese patients presented higher LPL activity than controls, and unlike the controls, this enzyme could be synthesized in the liver because it also present LPL mRNA. The presence of the LPL activity could enable the liver to capture circulating triacylglycerides, thus favoring the typical steatosis observed in these patients.

Keywords

Metabolic syndromeHepatic steatosisNAFLDNASHLPL

Abbreviations

NAFLD

non-alcoholic fatty liver disease

LPL

lipoprotein lipase

FFA

free fatty acids

ALT

alanine aminotransferase

AST

aspartate aminotransferase

HOMA-IR

homeostasis model assessment of insulin resistance

Copyright information

© Springer Science + Business Media, LLC 2009