Obesity Surgery

, Volume 19, Issue 5, pp 565–570

The Effect of Roux-en-Y Gastric Bypass on Gastroesophageal Reflux Disease in Morbidly Obese Chinese Patients

Authors

  • Chi-Ming Tai
    • Department of Internal MedicineE-DA Hospital and I-Shou University
    • Institute of Clinical Medicine, College of MedicineKaohsiung Medical University
    • Department of Internal MedicineNational Taiwan University Hospital
    • Division of Biostatistics, Graduate Institute of Epidemiology, College of Public HealthNational Taiwan University
    • Department of Internal Medicine, College of MedicineNational Taiwan University
  • Ming-Shiang Wu
    • Department of Internal MedicineNational Taiwan University Hospital
  • Chi-Yang Chang
    • Department of Internal MedicineE-DA Hospital and I-Shou University
  • Ching-Tai Lee
    • Department of Internal MedicineE-DA Hospital and I-Shou University
  • Chih-Kun Huang
    • Department of Surgery, E-Da HospitalI-Shou University
  • Hsin-Chih Kuo
    • Department of Health ManagementI-Shou University
    • Department of Internal MedicineE-DA Hospital and I-Shou University
    • Department of Internal MedicineNational Taiwan University Hospital
Research Article

DOI: 10.1007/s11695-008-9731-4

Cite this article as:
Tai, C., Lee, Y., Wu, M. et al. OBES SURG (2009) 19: 565. doi:10.1007/s11695-008-9731-4

Abstract

Background

The prevalence of gastroesophageal reflux disease (GERD) is increasing in Eastern and Western countries. Obesity is recognized as a risk factor of gastroesophageal reflux disease. However, little information is available on the prevalence of gastroesophageal reflux disease in morbidly obese Chinese patients. The aim of this study was to compare the prevalence of GERD in Chinese patients with morbid obesity and age- and sex-matched controls, and we also assessed the effect of Roux-en-Y gastric bypass on reflux symptoms and erosive esophagitis.

Methods

Between November 2006 and February 2008, 150 morbidly obese Chinese patients underwent laparoscopic Roux-en-Y gastric bypass. Gastroesophageal reflux disease questionnaires and esophagogastroduodenoscopy results were assessed in all cases before surgery. The prevalence of reflux symptoms and erosive esophagitis was compared with the prevalence in a database of 300 age- and sex-matched controls. We also compared baseline and postoperative characteristics at 12 months after operation.

Results

Patients with morbid obesity had higher frequencies of reflux symptoms (16% vs. 8%, P = 0.01) and erosive esophagitis (34% vs. 17%, P < 0.01) than those of controls. Twelve months after laparoscopic Roux-en-Y gastric bypass, 26 patients received follow-up evaluations. In addition to substantial weight loss, the prevalence of reflux symptoms and erosive esophagitis decreased significantly after operation (19.2% vs. 0%, P = 0.05, and 42.3% vs. 3.8%, P < 0.01, respectively).

Conclusions

Gastroesophageal reflux disease is pervasive in Chinese patients with morbid obesity and Roux-en-Y gastric bypass substantially improves not only the reflux symptoms but also the erosive esophagitis.

Keywords

Gastroesophageal reflux diseaseErosive esophagitisMorbid obesityBariatric surgeryRoux-en-Y gastric bypass

Abbreviations

GERD

gastroesophageal reflux disease

BMI

body mass index

LRYGB

laparoscopic Roux-en-Y gastric bypass

NCEP-ATP III

National Cholesterol Education Program’s Adult Treatment Panel III

EGD

esophagogastroduodenoscopy

LA classification

Los Angeles classification

Copyright information

© Springer Science + Business Media, LLC 2008