Obesity Surgery

, Volume 18, Issue 12, pp 1532–1538

Ursodeoxycholic Acid in the Prevention of Gallstone Formation after Bariatric Surgery: A Meta-analysis

  • Manley C. Uy
  • Marilyn C. Talingdan-Te
  • Wendell Z. Espinosa
  • Ma. Lourdes O. Daez
  • Janus P. Ong
Other

DOI: 10.1007/s11695-008-9587-7

Cite this article as:
Uy, M.C., Talingdan-Te, M.C., Espinosa, W.Z. et al. OBES SURG (2008) 18: 1532. doi:10.1007/s11695-008-9587-7

Abstract

Background

Rapid weight loss increases risk for gallstone formation. Prophylactic cholecystectomy is difficult. Several small trials have shown that ursodeoxycholic acid (UDCA) may prevent gallstone formation after bariatric surgery. The aim of this study is to assess the efficacy and safety of UDCA in the prevention of gallstone formation after bariatric surgery.

Methods

Electronic databases, including the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, Australasian Medical Index, LILACS, and HERDIN, were searched. Reference lists of trials selected by the above electronic searching were also searched. Authors of the retrieved trials and pharmaceutical companies were also contacted for other trials, published and unpublished. A meta-analysis of all randomized, double-blind, placebo-controlled prospective trials comparing UDCA and placebo was performed.

Results

Five RCTs including 521 patients were assessed. Random effects meta-analysis showed a significant reduction of gallstone formation (RR 0.43, 95% confidence interval 0.22–0.83), with 8.8% of those taking UDCA developing gallstones compared to 27.7% for placebo. Although this meta-analysis is heterogeneous with I2 of 61.9%, the directions of the effect are all consistently in favor of UDCA (p = 0.01). A meta-analysis on the adverse effects could not be performed because the studies did not report them in a way to make the analysis possible.

Conclusions

UDCA can prevent gallstone formation after bariatric surgery.

Keyword

Ursodeoxycholic acid Gallstone Bariatric surgery Meta-analysis 

Copyright information

© Springer Science + Business Media, LLC 2008

Authors and Affiliations

  • Manley C. Uy
    • 1
  • Marilyn C. Talingdan-Te
    • 1
  • Wendell Z. Espinosa
    • 1
  • Ma. Lourdes O. Daez
    • 1
  • Janus P. Ong
    • 1
  1. 1.Section of Gastroenterology, Department of Medicine, Philippine General HospitalUniversity of the PhilippinesManilaPhilippines

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