Obesity Surgery

, Volume 18, Issue 11, pp 1450–1454

The Eradication of Helicobacter pylori is Affected by Body Mass Index (BMI)

Authors

  • Mohamed Abdullahi
    • Gastrointestinal Unit, Department of Clinical SciencesUniversity La Sapienza
  • Bruno Annibale
    • Digestive and Liver Disease Unit, S. Andrea Hospital, 2nd Medical SchoolUniversity La Sapienza
  • Danila Capoccia
    • Endocrinology Unit, Department of Clinical SciencesUniversity La Sapienza
  • Roberto Tari
    • Gastrointestinal Unit, Department of Clinical SciencesUniversity La Sapienza
  • Edith Lahner
    • Digestive and Liver Disease Unit, S. Andrea Hospital, 2nd Medical SchoolUniversity La Sapienza
  • John Osborn
    • Department of Public Health SciencesUniversity La Sapienza
  • Frida Leonetti
    • Endocrinology Unit, Department of Clinical SciencesUniversity La Sapienza
    • Gastrointestinal Unit, Department of Clinical SciencesUniversity La Sapienza
Research Article

DOI: 10.1007/s11695-008-9477-z

Cite this article as:
Abdullahi, M., Annibale, B., Capoccia, D. et al. OBES SURG (2008) 18: 1450. doi:10.1007/s11695-008-9477-z

Abstract

Background

Bariatric surgeons often advocate preoperative Helicobacter pylori (H. pylori) testing and eradication because of the increased risk of postoperative ulcers and foregut symptoms in H. pylori-positive patients. The aim of this pilot study was to evaluate whether body mass index (BMI) might influence the success rate of eradication.

Methods

Eighty one nondiabetic naïve H. pylori-positive patients were divided into two groups according to their BMI, with 41 in the control group (normal BMI) and 40 in the overweight/obese group (BMI ≥25). Gastroscopy was performed and multiple biopsies were obtained from the antrum and corpus. Both groups were given a triple therapy consisting of pantoprazole 40 mg for 2 weeks plus amoxicillin 1 g tris in die (t.i.d), and clarithromycin 250 mg t.i.d, for the first week of treatment. Eradication was confirmed by the 13C-urea breath test at 3 months.

Results

Successful eradication was observed in 55.0% of the overweight/obese group compared with 85.4% [p < 0.005; odds ratio (OR): 4.77; 95% confidence interval (CI): 1.64–13.87]. The distribution of age, gender, and smoking, as well as the proportion with corpus predominant gastritis (41.4% and 35.0% in control and overweight/obese groups, respectively), did not differ significantly between the two groups. Regression analysis showed that risk factors for treatment failure were BMI (p < 0.02) with an OR of 1.06 (95% CI: 1.01–1.11) and corpus-predominant gastritis (p < 0.001) with an OR of 8.74 (95% CI: 2.48–30.8).

Conclusion

Overweight/obese nondiabetic patients showed a significantly lower rate of eradication rate of H. pylori infection than controls. BMI and corpus-predominant gastritis appear to be independent risk factors for eradication failure.

Keywords

Bariatric surgeryBody mass indexHelicobacter pylori eradicationObesityOverweight

Copyright information

© Springer Science + Business Media, LLC 2008