Obesity Surgery

, Volume 18, Issue 4, pp 408–414

The Effects of Liposuction Removal of Subcutaneous Abdominal Fat on Lipid Metabolism are Independent of Insulin Sensitivity in Normal-Overweight Individuals

  • J. Ybarra
  • F. Blanco-Vaca
  • S. Fernández
  • A. Castellví
  • R. Bonet
  • X. Palomer
  • J. Ordóñez-Llanos
  • A. Trius
  • R. Vila-Rovira
  • A. Pérez
Research Article

DOI: 10.1007/s11695-007-9261-5

Cite this article as:
Ybarra, J., Blanco-Vaca, F., Fernández, S. et al. OBES SURG (2008) 18: 408. doi:10.1007/s11695-007-9261-5

Abstract

Background

Abdominal fat (both visceral and subcutaneous) accumulation is associated with an increased risk of developing insulin resistance. The latter stands as the basis upon which diabetes, hypertension, and atherogenic dyslipidemia tend to build up. Hence, abdominal liposuction (AL) could theoretically hold metabolic benefits. We undertook the present study to assess the effects of AL on carbohydrate and lipid metabolism.

Methods

This is a prospective study including 20 healthy volunteers (M2/F18) aged 39.6 ± 7.7 years old (24–52), body mass index (BMI) = 25.3 ± 4.7 kg/m2 (19.8–36) who underwent AL. Before and 4 months after AL, we measured glucose and insulin concentrations, HOMA index [glucose (mM) × IRI (μUI/l)/22.5], free fatty acids (FFA), glycerol, total cholesterol and triglycerides, high-density lipoprotein (HDL)-cholesterol (HDL-c), low-density lipoprotein (LDL)-cholesterol (LDL-c), very low-density lipoprotein (VLDL)-cholesterol (VLDL-c) and apolipoproteins (apo) B, AI and AII, adiponectin (Adp), and ultra-sensitive C-reactive protein (CRP).

Results

Lipo-aspirate averaged 5.494 ± 5.297 cc (600–19.000). Weight, BMI, and waist circumference decreased significantly 4 months after surgery by 4.6, 4.6 and 5.9%, respectively. There were significant decrements in FFA (−35%, p < 0.0001), glycerol (−63%, p < 0.0005), VLDL-c (−15.2%; p < 0.001), and triglycerides (−21.3%, p < 0.002), an increase in HDL-c (+10%, p < 0.03), Apo AI (+10.1%, p < 0.02), and Apo AII (+11.8%, p < 0.001). Total cholesterol, LDL-c, ApoB, and the LDL-c/ApoB ratio raised by +15% (p < 0.0005), +27.3% (p < 0.000), +15.1% (p < 0.008) and +2.76% (p < 0.008), respectively. Glucose, insulin, the HOMA index, Adp, and CRP were not significantly altered after AL.

Conclusion

AL in healthy normal weight or slightly overweight subjects improves the major lipoprotein components of obesity-associated dyslipidemia. This improvement occurs independent of insulin sensitivity.

Keywords

Abdominal liposuction Lipoproteins Fatty acids Insulin resistance Adiponectin C reactive protein 

Copyright information

© Springer Science + Business Media B.V. 2007

Authors and Affiliations

  • J. Ybarra
    • 1
  • F. Blanco-Vaca
    • 2
  • S. Fernández
    • 2
  • A. Castellví
    • 2
  • R. Bonet
    • 2
  • X. Palomer
    • 2
  • J. Ordóñez-Llanos
    • 2
  • A. Trius
    • 3
  • R. Vila-Rovira
    • 3
  • A. Pérez
    • 1
  1. 1.Servicio de Endocrinología y NutriciónHospital de la Santa Creu i de Sant Pau e Institut Vila-RoviraBarcelonaSpain
  2. 2.Servicio de Endocrinología y BioquímicaBarcelonaSpain
  3. 3.Hospital de la Santa Creu i de Sant Pau e Institut Vila-Rovira (Centro Médico Teknon)BarcelonaSpain