Comparison of Anterior Gastric Wall and Greater Gastric Curvature Invaginations for Weight Loss in Rats
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Many bariatric endoscopic or surgical procedures performed today reduce gastric capacity and/or induce an early sensation of gastric satiety, alone or in combination with a distal enteric intervention. A form of prosthetic wrap of the folded stomach was used in the past for treating obesity with a high rate of prosthesis-related reintervention. Nissen gastric fundoplication used in the treatment of gastroesophageal reflux disease induces a small but significant weight loss without gastric stapling, partitioning, or prosthesis-related morbidity. We recently reported greater gastric curvature invagination without stapling, partitioning or prosthesis use, for weight loss in rats.We now compare anterior gastric wall and greater gastric curvature invaginations for weight loss. The anterior invagination would be technically easier, should it be tested in humans.
20 rats were randomized in 2 groups. The anterior gastric wall of 10 rats was invaginated in the first group (AGW). The greater gastric curvature of 10 rats was invaginated in the second group (GGC). All animals were weighed weekly for 4 weeks. They were then autopsied on the 28th day.
The mean body weight of the GGC group became statistically less than the AGW group at 21 days. The mean weight of the peritesticular fat pad and the mean gastric volume were not statistically different at 28 days (autopsy).
Greater gastric curvature invagination significantly reduces body weight compared to anterior gastric wall invagination at 21 days.
- Mason EE, Printen KJ, Hartford CE et al. Optimizing results of gastric bypass. Ann Surg 1975; 182: 405–14. CrossRef
- Torres JC, Oca CF, Garrison RN. Gastric bypass: Roux-en-Y gastrojejunostomy from the lesser curvature. South Med J 1983; 76: 1217–21.
- Mason EE. Morbid obesity: use of vertical banded gastroplasty. Surg Clin North Am 1987; 67: 521–37.
- Belachew M, Legrand MJ, Vincenti VV et al. Laparoscopic placement of adjustable silicone gastric band in the treatment of morbid obesity: How to do it. Obes Surg 1995; 5: 66–70. CrossRef
- Scopinaro N, Gianetta E, Civalleri D et al. Bilio-pancreatic bypass for obesity: II. Initial experience in man. Br J Surg 1979; 66: 618–20. CrossRef
- Lagace M, Marceau P, Marceau S et al. Biliopancreatic diversion with a new type of gastrectomy: some previous conclusions revisited. Obes Surg 1995; 5: 411–8. CrossRef
- Cossu ML, Noya G, Tonolo GC et al. Duodenal switch without gastric resection: results and observations after 6 years. Obes Surg 2004; 14: 1354–9. CrossRef
- Himpens J, Dapri G, Cadiere GB. A prospective randomized study between laparoscopic gastric banding and laparoscopic isolated sleeve gastrectomy: results after 1 and 3 years. Obes Surg 2006; 16: 1450–6. CrossRef
- Mognol P, Chosidow D, Marmuse JP. Hepatic portal gas due to gastro-jejunal anastomotic leak after laparoscopic gastric bypass. Obes Surg 2005; 15: 278–81. CrossRef
- Goitein D, Papasavas PK, Gagne D et al. Gastrojejunal strictures following laparoscopic Rouxen-Y gastric bypass for morbid obesity. Surg Endosc 2005; 19: 628–32. CrossRef
- Nguyen NT, Longoria M, Chalifoux S et al. Gastrointestinal hemorrhage after laparoscopic gastric bypass. Obes Surg 2004; 14: 1308–12. CrossRef
- Esmailzadeh H, Powell W, Lourie D. Use of computed tomography in diagnosis of major postoperative gastrointestinal complications of laparoscopic Roux-en-Y gastric bypass surgery. Am Surg 2004; 70: 964–6.
- Lunca S, Vix M, Rikkers A et al. Late gastric prolapse with pouch necrosis after laparoscopic adjustable gastric banding. Obes Surg 2005; 15: 571–5. CrossRef
- Stelzmueller I, Hoeller E, Wiesmayr S et al. Severe intra-abdominal infection due to streptococcus milleri following adjustable gastric banding. Obes Surg 2005; 15: 576–9. CrossRef
- Weiss H, Nehoda H, Labeck B et al. Injection port complications after gastric banding: incidence, management and prevention. Obes Surg 2000; 10: 259–62. CrossRef
- Bueter M, Thalheimer A, Meyer D et al. Band erosion and passage, causing small bowel obstruction. Obes Surg 2006; 16: 1679–82. CrossRef
- Forsell P, Hallerbäck B, Glise H et al. Complications following Swedish adjustable gastric banding: a longterm follow-up. Obes Surg 1999; 9: 11–6. CrossRef
- Niville E, Dams A, Van Der Speeten K et al. Results of lap rebanding procedures after Lap-Band removal for band erosion — a mid-term evaluation. Obes Surg 2005; 15: 630–3. CrossRef
- Chevallier JM, Zinzindohoué F, Douard R et al. Complications after laparoscopic adjustable gastric banding for morbid obesity: experience with 1,000 patients over 7 years. Obes Surg 2004; 14: 407–14. CrossRef
- Zappa MA, Lattuada E, Mozzi E et al. An unusual complication of gastric banding: recurrent small bowel obstruction caused by the connecting tube. Obes Surg 2006; 16: 939–41. CrossRef
- Camerini G, Adami GF, Marinari GM et al. Thirteen years of follow-up in patients with adjustable silicone gastric banding for morbid obesity: weight loss and constant rate of specific complications. Obes Surg 2004; 14: 1343–8. CrossRef
- Dargent J. Esophageal dilatation after laparoscopic adjustable gastric banding: definition and strategy. Obes Surg 2005; 15: 843–8. CrossRef
- Busetto L, Segato G, De Luca M et al. Preoperative weight loss by intragastric balloon in super-obese patients treated with laparoscopic gastric banding: a case-control study. Obes Surg 2004; 14: 671–6. CrossRef
- Giardiello C, Cristiano S, Cerbone MR et al. Gastric perforation in an obese patient with an intragastric balloon, following previous fundoplication. Obes Surg 2003; 13: 658–60. CrossRef
- Evans JD, Scott MH. Intragastric balloon in the treatment of patients with morbid obesity. Br J Surg 2001; 88: 1245–8. CrossRef
- Curley SA, Weaver W, Wilkinson LH et al. Late complications after gastric reservoir reduction with external wrap. Arch Surg 1987; 122: 781–3.
- Hoekstra SM, Lucas CE, Ledgerwood AM et al. A comparison of the gastric bypass and the gastric wrap for morbid obesity. Surg Gynecol Obstet 1993; 176: 262–6.
- Neumayer C, Ciovica R, Gadenstatter M et al. Significant weight loss after laparoscopic Nissen fundoplication. Surg Endosc 2005; 19: 15–20. CrossRef
- Finlayson SRG, Laycock WS, Birkmeyer JD. National trends in utilization and outcomes of antireflux surgery. Surg Endosc 2003; 17: 864–7. CrossRef
- Wykypiel H, Wetscher GJ, Klingler P et al. The Nissen fundoplication: indication, technical aspects and postoperative outcome. Langenbecks Arch Surg 2005; 390: 495–502. CrossRef
- Fusco PE, Poggetti RS, Younes RN et al. Evaluation of gastric greater curvature invagination for weight loss in rats. Obes Surg 2006; 16: 172–7. CrossRef
- O’Brien PE, McPhail T, Chaston TB et al. Systematic review of medium-term weight loss after bariatric operations. Obes Surg 2006; 16: 1032–40. CrossRef
- Comparison of Anterior Gastric Wall and Greater Gastric Curvature Invaginations for Weight Loss in Rats
Volume 17, Issue 10 , pp 1340-1345
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Surgical technique
- bariatric surgery
- morbid obesity
- Industry Sectors
- Author Affiliations
- 1. Department of Surgery, University of São Paulo Medical School, São Paulo, SP, Brazil
- 2. R. Dr. Renato Paes de Barros, n 750, cj. 33, São Paulo, SP, Brazil, 04530 001