Obesity Surgery

, Volume 17, Issue 8, pp 1069–1074

Short-term Effects of Sleeve Gastrectomy on Type 2 Diabetes Mellitus in Severely Obese Subjects

Authors

    • Obesity UnitHospital Clinic Universitari
    • Obesity UnitHospital Clínic Universitari
  • A. Ibarzabal
    • Obesity UnitHospital Clinic Universitari
  • J. Nicolau
    • Obesity UnitHospital Clinic Universitari
  • M. Vidov
    • Obesity UnitHospital Clinic Universitari
  • S. Delgado
    • Obesity UnitHospital Clinic Universitari
  • G. Martinez
    • Obesity UnitHospital Clinic Universitari
  • J. Balust
    • Obesity UnitHospital Clinic Universitari
  • R. Morinigo
    • Obesity UnitHospital Clinic Universitari
  • A. Lacy
    • Obesity UnitHospital Clinic Universitari
Research Articles

DOI: 10.1007/s11695-007-9180-5

Cite this article as:
Vidal, J., Ibarzabal, A., Nicolau, J. et al. OBES SURG (2007) 17: 1069. doi:10.1007/s11695-007-9180-5

Background

Data on the effectiveness of sleeve gastrectomy (SG) in improving or resolving type 2 diabetes mellitus (T2DM) are scarce.

Methods

A 4-month prospective study was conducted on the changes in glucose homeostasis in 35 severely obese T2DM subjects undergoing laparoscopic SG (LSG) and 50 subjects undergoing laparoscopic Roux-en-Y gastric bypass (LRYGBP), matched for DM duration, type of DM treatment, and glycemic control.

Results

At 4-months after surgery, LSG and LRYGBP operated subjects lost a similar amount of weight (respectively, 20.6 ± 0.7% and 21.0 ± 0.6%). T2DM had resolved respectively in 51.4% and 62.0% of the LSG and LRYGBP operated subjects (P = 0.332). A shorter preoperative DM duration (P < 0.05), a preoperative DM treatment not including pharmacological agents, and a better pre-surgical fasting plasma glucose (P < 0.01) or HbA1c (P < 0.01), were significantly associated with a better type 2 DM outcome in both surgical groups.

Conclusions

Our data show that LSG and LRYGBP result in a similar rate of type 2 DM resolution at 4-months after surgery. Moreover, our data suggest that mechanisms beyond weight loss may be implicated in DM resolution following LSG and LRYGBP.

Key words

Morbid obesitytype 2 diabetes mellitussleeve gastrectomygastric bypassinsulin sensitivityweight loss

Copyright information

© Springer Science + Business Media B.V. 2007