Frontiers of Medicine

, Volume 7, Issue 3, pp 306–315

Advancement of human leukocyte antigen-partially matched related hematopoietic stem cell transplantation

Authors

  • Xiaodong Mo
    • Peking University People’s Hospital & Institute of HematologyBeijing Key Laboratory of Hematopoietic Stem Cell Transplantation
    • Peking University People’s Hospital & Institute of HematologyBeijing Key Laboratory of Hematopoietic Stem Cell Transplantation
Review

DOI: 10.1007/s11684-013-0279-x

Cite this article as:
Mo, X. & Huang, X. Front. Med. (2013) 7: 306. doi:10.1007/s11684-013-0279-x

Abstract

Allogeneic hematopoietic stem cell transplantation (HSCT) is one of the most effective options for hematological malignancies, and human leukocyte antigen-partially matched related donors (PMRDs) are a valuable option for HSCT. Several protocols (with or without ex vivo T-cell depletion (TCD)) have been established worldwide. TCD including CD34+ positive selection and CD3/CD19 depletion has successfully overcome the human leukocyte antigen disparity. However, TCD is associated with prolonged immune deficiencies, increased risks of infectious complications, and high transplantation-related mortality. PMRD HSCTwithout ex vivo TCD is well developed, and numerous patients have benefitted from it. Here, we review the literature on PMRD HSCT.

Keywords

partially matched related donorhematopoietic stem cell transplantationallogeneic

Copyright information

© Higher Education Press and Springer-Verlag Berlin Heidelberg 2013