Frontiers of Medicine

, Volume 7, Issue 2, pp 207–222

Leptin signaling and leptin resistance


DOI: 10.1007/s11684-013-0263-5

Cite this article as:
Zhou, Y. & Rui, L. Front. Med. (2013) 7: 207. doi:10.1007/s11684-013-0263-5


Leptin is secreted into the bloodstream by adipocytes and is required for the maintenance of energy homeostasis and body weight. Leptin deficiency or genetic defects in the components of the leptin signaling pathways cause obesity. Leptin controls energy balance and body weight mainly through leptin receptor b (LEPRb)-expressing neurons in the brain, particularly in the hypothalamus. These LEPRb-expressing neurons function as the first-order neurons that project to the second-order neurons located within and outside the hypothalamus, forming a neural network that controls the energy homeostasis and body weight. Multiple factors, including inflammation and endoplasmic reticulum (ER) stress, contribute to leptin resistance. Leptin resistance is the key risk factor for obesity. This review is focused on recent advance about leptin action, leptin signaling, and leptin resistance.


leptin signalingleptin receptorenergy balanceleptin resistanceobesity

Copyright information

© Higher Education Press and Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Cambridge LaboratoriesPfizer Worldwide Research & DevelopmentCambridgeUSA
  2. 2.Department of Molecular and Integrative PhysiologyUniversity of Michigan Medical SchoolAnn ArborUSA