Molecular targeted therapy of gynecological malignant tumors: the development and challenge, from laboratory to clinic
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- Sun, P., Sehouli, J. & Wei, L. Front. Med. China (2009) 3: 256. doi:10.1007/s11684-009-0052-3
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More and more molecular drugs based on targeted therapy have been utilized in the treatment of gynecologic cancer, especially in ovarian cancer. In this article, we systematically review the current targeted therapeutic trials running in clinic. Large, randomized trials have been conducted in the treatment of ovarian cancer, endometrial cancer and cervical cancer by usingsmall molecule, antisense, mutational gene as well as antibodies. Other planned or ongoing trials currently targeted at molecular markers which may play important roles in gynecological carcinogenesis and progression suggest that combination chemotherapy with molecular targeted therapy will ultimately be an important option.