Frontiers of Medicine in China

, Volume 3, Issue 3, pp 256–264

Molecular targeted therapy of gynecological malignant tumors: the development and challenge, from laboratory to clinic

Authors

  • Pengming Sun
    • Institute of Gynecologic Oncology, Fujian Provincial Women and Children’s HospitalFujian Medical University
    • Department of GynecologyCampus Virchow Klinikum
  • Jalid Sehouli
    • Department of GynecologyCampus Virchow Klinikum
    • Department of GynecologyPeking University People’s Hospital
Review

DOI: 10.1007/s11684-009-0052-3

Cite this article as:
Sun, P., Sehouli, J. & Wei, L. Front. Med. China (2009) 3: 256. doi:10.1007/s11684-009-0052-3
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Abstract

More and more molecular drugs based on targeted therapy have been utilized in the treatment of gynecologic cancer, especially in ovarian cancer. In this article, we systematically review the current targeted therapeutic trials running in clinic. Large, randomized trials have been conducted in the treatment of ovarian cancer, endometrial cancer and cervical cancer by usingsmall molecule, antisense, mutational gene as well as antibodies. Other planned or ongoing trials currently targeted at molecular markers which may play important roles in gynecological carcinogenesis and progression suggest that combination chemotherapy with molecular targeted therapy will ultimately be an important option.

Keywords

target therapygynecologic malignant tumorsclinical trailmolecular medicine

Copyright information

© Higher Education Press and Springer-Verlag GmbH 2009