Brain Imaging and Behavior

, Volume 7, Issue 4, pp 511–523

The association between pro-inflammatory cytokines, regional cerebral metabolism, and cognitive complaints following adjuvant chemotherapy for breast cancer

  • K. L. Pomykala
  • P. A. Ganz
  • J. E. Bower
  • L. Kwan
  • S. A. Castellon
  • S. Mallam
  • I. Cheng
  • R. Ahn
  • E. C. Breen
  • M. R. Irwin
  • D. H. S. Silverman
SI: Neuroimaging Studies of Cancer and Cancer Treatment

DOI: 10.1007/s11682-013-9243-2

Cite this article as:
Pomykala, K.L., Ganz, P.A., Bower, J.E. et al. Brain Imaging and Behavior (2013) 7: 511. doi:10.1007/s11682-013-9243-2

Abstract

To examine relationships following adjuvant chemotherapy between circulating pro-inflammatory cytokines, regional cerebral metabolism, and cognitive complaints in early stage breast cancer patients. 33 breast cancer patients who had completed initial treatment (surgery, ± radiation, 23 chemotherapy, 10 no chemotherapy) obtained resting (18)F-FDG PET/CT brain imaging at baseline and 1 year later. Pro-inflammatory cytokine markers (IL-1ra, sTNF-RII, CRP, and IL-6) and cognitive complaints were also assessed at both time points. At baseline, consistent correlations were seen between the left medial frontal and right inferior lateral anterior temporal cortices and inflammatory markers within the chemotherapy group, and not in the no chemotherapy group. After 1 year, correlations persisted in the medial frontal cortex and the temporal cortex, the latter shifting superiorly. Both of these regional correlations demonstrated the highest levels of significance when looking across the 1 year time frame (IL-1ra: peak voxel p < 0.0005; cluster size p < 0.0005, p = 0.001 after correction (medial prefrontal), p < 0.0005; cluster size p = 0.001, p = 0.029 corr. (anterior temporal), sTNF-RII: p < 0.0005; cluster size p = 0.001, p = 0.040 corr. (medial prefrontal)). Positive correlations were also seen within the chemotherapy group between baseline memory complaints and the medial frontal (p < 0.0005; cluster size p < 0.0005, p < 0.0005 corr.) and anterior temporal (p < 0.0005; cluster size p < 0.0005, p = 0.002 corr.) cortices at baseline and 1 year later. Metabolism in the medial prefrontal cortex and anterior temporal cortex was found to correlate with both memory complaints and cytokine marker levels in chemotherapy patients.

Keywords

Positron emission tomography Brain imaging Breast cancer Cognitive complaints Chemotherapy Pro-inflammatory cytokines 

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • K. L. Pomykala
    • 1
  • P. A. Ganz
    • 2
    • 3
    • 4
  • J. E. Bower
    • 4
    • 5
    • 6
  • L. Kwan
    • 4
  • S. A. Castellon
    • 7
    • 8
  • S. Mallam
    • 1
  • I. Cheng
    • 1
  • R. Ahn
    • 1
  • E. C. Breen
    • 6
    • 8
  • M. R. Irwin
    • 5
    • 6
    • 8
  • D. H. S. Silverman
    • 1
  1. 1.Department of Molecular and Medical PharmacologyDavid Geffen School of Medicine at UCLALos AngelesUSA
  2. 2.Department of Health Policy & ManagementUCLA Fielding School of Public HealthLos AngelesUSA
  3. 3.Department of MedicineDavid Geffen School of Medicine at UCLALos AngelesUSA
  4. 4.Division of Cancer Prevention and Control ResearchJonsson Comprehensive Cancer Center at UCLALos AngelesUSA
  5. 5.Department of PsychologyUniversity of CaliforniaLos AngelesUSA
  6. 6.Cousins Center of PsychoneuroimmunologySemel Institute for NeuroscienceLos AngelesUSA
  7. 7.VA Greater Los Angeles Health Care SystemLos AngelesUSA
  8. 8.Department of Psychiatry and Biobehavioral SciencesDavid Geffen School of Medicine at UCLALos AngelesUSA