SI: Neuroimaging Studies of Cancer and Cancer Treatment

Brain Imaging and Behavior

, Volume 7, Issue 4, pp 511-523

The association between pro-inflammatory cytokines, regional cerebral metabolism, and cognitive complaints following adjuvant chemotherapy for breast cancer

  • K. L. PomykalaAffiliated withDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA
  • , P. A. GanzAffiliated withDepartment of Health Policy & Management, UCLA Fielding School of Public HealthDepartment of Medicine, David Geffen School of Medicine at UCLADivision of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center at UCLA
  • , J. E. BowerAffiliated withDivision of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center at UCLADepartment of Psychology, University of CaliforniaCousins Center of Psychoneuroimmunology, Semel Institute for Neuroscience
  • , L. KwanAffiliated withDivision of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center at UCLA
  • , S. A. CastellonAffiliated withVA Greater Los Angeles Health Care SystemDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA
  • , S. MallamAffiliated withDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA
  • , I. ChengAffiliated withDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA
  • , R. AhnAffiliated withDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA
  • , E. C. BreenAffiliated withCousins Center of Psychoneuroimmunology, Semel Institute for NeuroscienceDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA
    • , M. R. IrwinAffiliated withDepartment of Psychology, University of CaliforniaCousins Center of Psychoneuroimmunology, Semel Institute for NeuroscienceDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA
    • , D. H. S. SilvermanAffiliated withDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA Email author 

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Abstract

To examine relationships following adjuvant chemotherapy between circulating pro-inflammatory cytokines, regional cerebral metabolism, and cognitive complaints in early stage breast cancer patients. 33 breast cancer patients who had completed initial treatment (surgery, ± radiation, 23 chemotherapy, 10 no chemotherapy) obtained resting (18)F-FDG PET/CT brain imaging at baseline and 1 year later. Pro-inflammatory cytokine markers (IL-1ra, sTNF-RII, CRP, and IL-6) and cognitive complaints were also assessed at both time points. At baseline, consistent correlations were seen between the left medial frontal and right inferior lateral anterior temporal cortices and inflammatory markers within the chemotherapy group, and not in the no chemotherapy group. After 1 year, correlations persisted in the medial frontal cortex and the temporal cortex, the latter shifting superiorly. Both of these regional correlations demonstrated the highest levels of significance when looking across the 1 year time frame (IL-1ra: peak voxel p < 0.0005; cluster size p < 0.0005, p = 0.001 after correction (medial prefrontal), p < 0.0005; cluster size p = 0.001, p = 0.029 corr. (anterior temporal), sTNF-RII: p < 0.0005; cluster size p = 0.001, p = 0.040 corr. (medial prefrontal)). Positive correlations were also seen within the chemotherapy group between baseline memory complaints and the medial frontal (p < 0.0005; cluster size p < 0.0005, p < 0.0005 corr.) and anterior temporal (p < 0.0005; cluster size p < 0.0005, p = 0.002 corr.) cortices at baseline and 1 year later. Metabolism in the medial prefrontal cortex and anterior temporal cortex was found to correlate with both memory complaints and cytokine marker levels in chemotherapy patients.

Keywords

Positron emission tomography Brain imaging Breast cancer Cognitive complaints Chemotherapy Pro-inflammatory cytokines