Brain Imaging and Behavior

, Volume 7, Issue 4, pp 478–490

A prospective evaluation of changes in brain structure and cognitive functions in adult stem cell transplant recipients

Authors

    • Department of NeurologyMemorial Sloan-Kettering Cancer Center
    • Department of Neurology & NeuroscienceWeill Cornell Medical College
  • J. C. Root
    • Department of Psychiatry & Behavioral SciencesMemorial Sloan-Kettering Cancer Center
    • Department of PsychiatryWeill Cornell Medical College
  • R. Baser
    • Department of Epidemiology & BiostatisticsMemorial Sloan-Kettering Cancer Center
  • D. Moore
    • Department of Neurology & NeuroscienceWeill Cornell Medical College
  • K. K. Peck
    • Department of RadiologyMemorial Sloan-Kettering Cancer Center
    • Department of RadiologyWeill Cornell Medical College
  • E. Lis
    • Department of RadiologyMemorial Sloan-Kettering Cancer Center
    • Department of RadiologyWeill Cornell Medical College
  • T. B. Shore
    • Department of MedicineWeill Cornell Medical College
  • H. T. Thaler
    • Department of Epidemiology & BiostatisticsMemorial Sloan-Kettering Cancer Center
  • A. Jakubowski
    • Department of MedicineMemorial Sloan-Kettering Cancer Center
    • Department of MedicineWeill Cornell Medical College
  • N. Relkin
    • Department of Neurology & NeuroscienceWeill Cornell Medical College
SI: Neuroimaging Studies of Cancer and Cancer Treatment

DOI: 10.1007/s11682-013-9221-8

Cite this article as:
Correa, D.D., Root, J.C., Baser, R. et al. Brain Imaging and Behavior (2013) 7: 478. doi:10.1007/s11682-013-9221-8

Abstract

Hematopoietic stem cell transplantation (HSCT) is an efficacious treatment for many hematologic malignancies. However, the conditioning regimen of high-dose (HD) chemotherapy with or without total body irradiation (TBI) can be associated with neurotoxicity. In this prospective study, we used quantitative neuroimaging techniques to examine regional gray matter and ventricular volumes, and standardized neuropsychological tests to assess cognitive function before and 1 year after HSCT in 28 patients with hematologic malignancies and in ten healthy controls evaluated at similar intervals. Nineteen patients received conditioning treatment with HD chemotherapy alone and nine had both TBI and HD chemotherapy. There was a significant reduction in gray matter volume in the middle frontal gyrus bilaterally and in the left caudate nucleus in the patient group (all patients combined) but not among healthy controls over the 1-year follow-up period. There was a significant increase in left lateral ventricle volume and in total ventricle volume in the patient group, relative to healthy controls. Similar brain structural changes were seen for patients treated with HD chemotherapy alone. The neuropsychological results showed that 21 % of patients could be classified as impaired at baseline. The Reliable Change Index suggested no significantly different rates of cognitive decline between patients and healthy controls. The findings suggest that HSCT patients may be at an increased risk for developing regional brain volume loss, and that subgroups may experience cognitive dysfunction prior to and 1 year following the transplant.

Keywords

Hematopoietic stem cell transplantationCognitiveStructural neuroimagingVoxel-based morphometry

Copyright information

© Springer Science+Business Media New York 2013