Brain Imaging and Behavior

, Volume 6, Issue 4, pp 568–583

Relationship between baseline brain metabolism measured using [18F]FDG PET and memory and executive function in prodromal and early Alzheimer’s disease

  • Christian Habeck
  • Shannon Risacher
  • Grace J. Lee
  • M. Maria Glymour
  • Elizabeth Mormino
  • Shubhabrata Mukherjee
  • Sungeun Kim
  • Kwangsik Nho
  • Charles DeCarli
  • Andrew J. Saykin
  • Paul K. Crane
  • for the Alzheimer’s Disease Neuroimaging Initiative
ADNI: Friday Harbor 2011 Workshop SPECIAL ISSUE

DOI: 10.1007/s11682-012-9208-x

Cite this article as:
Habeck, C., Risacher, S., Lee, G.J. et al. Brain Imaging and Behavior (2012) 6: 568. doi:10.1007/s11682-012-9208-x

Abstract

Differences in brain metabolism as measured by FDG-PET in prodromal and early Alzheimer’s disease (AD) have been consistently observed, with a characteristic parietotemporal hypometabolic pattern. However, exploration of brain metabolic correlates of more nuanced measures of cognitive function has been rare, particularly in larger samples. We analyzed the relationship between resting brain metabolism and memory and executive functioning within diagnostic group on a voxel-wise basis in 86 people with AD, 185 people with mild cognitive impairment (MCI), and 86 healthy controls (HC) from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). We found positive associations within AD and MCI but not in HC. For MCI and AD, impaired executive functioning was associated with reduced parietotemporal metabolism, suggesting a pattern consistent with known AD-related hypometabolism. These associations suggest that decreased metabolic activity in the parietal and temporal lobes may underlie the executive function deficits in AD and MCI. For memory, hypometabolism in similar regions of the parietal and temporal lobes were significantly associated with reduced performance in the MCI group. However, for the AD group, memory performance was significantly associated with metabolism in frontal and orbitofrontal areas, suggesting the possibility of compensatory metabolic activity in these areas. Overall, the associations between brain metabolism and cognition in this study suggest the importance of parietal and temporal lobar regions in memory and executive function in the early stages of disease and an increased importance of frontal regions for memory with increasing impairment.

Keywords

Mild cognitive impairment (MCI) Alzheimer’s disease (AD) FDG PET Memory Executive function 

Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Christian Habeck
    • 1
  • Shannon Risacher
    • 2
  • Grace J. Lee
    • 3
  • M. Maria Glymour
    • 4
  • Elizabeth Mormino
    • 5
  • Shubhabrata Mukherjee
    • 6
  • Sungeun Kim
    • 2
  • Kwangsik Nho
    • 2
  • Charles DeCarli
    • 7
  • Andrew J. Saykin
    • 2
  • Paul K. Crane
    • 6
  • for the Alzheimer’s Disease Neuroimaging Initiative
  1. 1.Cognitive Neuroscience DivisionThe Taub Institute for Research on Aging and Alzheimer’s Disease, Columbia UniversityNew YorkUSA
  2. 2.Department of Radiology and Imaging SciencesCenter for Neuroimaging, Indiana University School of MedicineIndianapolisUSA
  3. 3.Department of NeurologyUniversity of California at Los AngelesLos AngelesUSA
  4. 4.Department of Society, Human Development, and HealthHarvard School of Public HealthBostonUSA
  5. 5.Department of NeurologyHarvard Medical SchoolBostonUSA
  6. 6.Department of MedicineUniversity of WashingtonSeattleUSA
  7. 7.Department of Neurology and Center for NeuroscienceUniversity of California at DavisSacramentoUSA

Personalised recommendations