Brain Imaging and Behavior

, Volume 6, Issue 4, pp 551–567

Voxel and surface-based topography of memory and executive deficits in mild cognitive impairment and Alzheimer’s disease

Authors

  • Kwangsik Nho
    • Center for Neuroimaging, Department of Radiology and Imaging SciencesIndiana University School of Medicine
  • Shannon L. Risacher
    • Center for Neuroimaging, Department of Radiology and Imaging SciencesIndiana University School of Medicine
  • Paul K. Crane
    • Department of MedicineUniversity of Washington
  • Charles DeCarli
    • Department of Neurology and the Center for Neuroscience, School of MedicineUniversity of California Davis
  • M. Maria Glymour
    • Department of Society, Human Development and HealthHarvard School of Public Health
  • Christian Habeck
    • Cognitive Neuroscience Division of Taub Institute for the Study of Alzheimer’s Disease and Aging BrainColumbia University College of Physicians and Surgeons
  • Sungeun Kim
    • Center for Neuroimaging, Department of Radiology and Imaging SciencesIndiana University School of Medicine
  • Grace J. Lee
    • Department of NeurologyDavid Geffen School of Medicine at UCLA
  • Elizabeth Mormino
    • Helen Wills Neuroscience InstituteUniversity of California Berkeley
  • Shubhabrata Mukherjee
    • Department of MedicineUniversity of Washington
  • Li Shen
    • Center for Neuroimaging, Department of Radiology and Imaging SciencesIndiana University School of Medicine
  • John D. West
    • Center for Neuroimaging, Department of Radiology and Imaging SciencesIndiana University School of Medicine
    • Center for Neuroimaging, Department of Radiology and Imaging SciencesIndiana University School of Medicine
  • Alzheimer’s Disease Neuroimaging Initiative (ADNI)
ADNI: Friday Harbor 2011 Workshop SPECIAL ISSUE

DOI: 10.1007/s11682-012-9203-2

Cite this article as:
Nho, K., Risacher, S.L., Crane, P.K. et al. Brain Imaging and Behavior (2012) 6: 551. doi:10.1007/s11682-012-9203-2

Abstract

Mild cognitive impairment (MCI) and Alzheimer’s disease (AD) are associated with a progressive loss of cognitive abilities. In the present report, we assessed the relationship of memory and executive function with brain structure in a sample of 810 Alzheimer’s Disease Neuroimaging Initiative (ADNI) participants, including 188 AD, 396 MCI, and 226 healthy older adults (HC). Composite scores of memory (ADNI-Mem) and executive function (ADNI-Exec) were generated by applying modern psychometric theory to item-level data from ADNI’s neuropsychological battery. We performed voxel-based morphometry (VBM) and surface-based association (SurfStat) analyses to evaluate relationships of ADNI-Mem and ADNI-Exec with grey matter (GM) density and cortical thickness across the whole brain in the combined sample and within diagnostic groups. We observed strong associations between ADNI-Mem and medial and lateral temporal lobe atrophy. Lower ADNI-Exec scores were associated with advanced GM and cortical atrophy across broadly distributed regions, most impressively in the bilateral parietal and temporal lobes. We also evaluated ADNI-Exec adjusted for ADNI-Mem, and found associations with GM density and cortical thickness primarily in the bilateral parietal, temporal, and frontal lobes. Within-group analyses suggest these associations are strongest in patients with MCI and AD. The present study provides insight into the spatially unbiased associations between brain atrophy and memory and executive function, and underscores the importance of structural brain changes in early cognitive decline.

Keywords

Voxel-based morphometry (VBM)Surface-based analysisMemoryExecutive functionAlzheimer’s diseaseMild cognitive impairment

Copyright information

© Springer Science+Business Media New York 2012