Brain Imaging and Behavior

, Volume 8, Issue 3, pp 407–419

Three approaches to investigating functional compromise to the default mode network after traumatic axonal injury

  • Ana Arenivas
  • Ramon Diaz-Arrastia
  • Jeffrey Spence
  • C. Munro Cullum
  • Kamini Krishnan
  • Christopher Bosworth
  • Carlee Culver
  • Beth Kennard
  • Carlos Marquez de la Plata
Neuroimaging and Rehabilitation SPECIAL ISSUE

DOI: 10.1007/s11682-012-9191-2

Cite this article as:
Arenivas, A., Diaz-Arrastia, R., Spence, J. et al. Brain Imaging and Behavior (2014) 8: 407. doi:10.1007/s11682-012-9191-2

Abstract

The default mode network (DMN) is a reliably elicited functional neural network with potential clinical implications. Its discriminant and prognostic utility following traumatic axonal injury (TAI) have not been previously investigated. The present study used three approaches to analyze DMN functional connectedness, including a whole-brain analysis [A1], network-specific analysis [A2], and between-node (edge) analysis [A3]. The purpose was to identify the utility of each method in distinguishing between healthy and brain-injured individuals, and determine whether observed differences have clinical significance. Resting-state fMRI was acquired from 25 patients with TAI and 17 healthy controls. Patients were scanned 6–11 months post-injury, and functional and neurocognitive outcomes were assessed the same day. Using all three approaches, TAI subjects revealed significantly weaker functional connectivity (FC) than controls, and binary logistic regressions demonstrated all three approaches have discriminant value. Clinical outcomes were not correlated with FC using any approach. Results suggest that compromise to the functional connectedness of the DMN after TAI can be identified using resting-state FC; however, the degree of functional compromise to this network, as measured in this study, may not have clinical implications in chronic TAI.

Keywords

Default mode networkFunctional connectivityTBIBiomarkerOutcomeTraumatic axonal injury

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Ana Arenivas
    • 1
  • Ramon Diaz-Arrastia
    • 2
    • 4
  • Jeffrey Spence
    • 3
  • C. Munro Cullum
    • 1
    • 2
  • Kamini Krishnan
    • 1
  • Christopher Bosworth
    • 1
  • Carlee Culver
    • 5
  • Beth Kennard
    • 1
  • Carlos Marquez de la Plata
    • 1
    • 5
  1. 1.Department of PsychiatryUniversity of Texas Southwestern Medical CenterDallasUSA
  2. 2.Department of Neurology and NeurotherapeuticsUniversity of Texas Southwestern Medical CenterDallasUSA
  3. 3.Department of Internal Medicine and Clinical SciencesUniversity of Texas Southwestern Medical CenterDallasUSA
  4. 4.Center for Neuroscience and Regenerative MedicineUniformed Services University of the Health ScienceRockvilleUSA
  5. 5.Center for BrainHealthUniversity of Texas at DallasDallasUSA