Brain Imaging and Behavior

, Volume 6, Issue 2, pp 208–223

Metabolic imaging of mild traumatic brain injury

  • A. P. Lin
  • H. J. Liao
  • S. K. Merugumala
  • S. P. Prabhu
  • W. P. MeehanIII
  • B. D. Ross
mTBI SPECIAL ISSUE

DOI: 10.1007/s11682-012-9181-4

Cite this article as:
Lin, A.P., Liao, H.J., Merugumala, S.K. et al. Brain Imaging and Behavior (2012) 6: 208. doi:10.1007/s11682-012-9181-4

Abstract

Traumatic brain injury results in a metabolic cascade of changes that occur at the molecular level, invisible to conventional imaging methods such as computed tomography or magnetic resonance imaging. Non-invasive metabolic imaging tools such as single photon emission computed tomography (SPECT), positron emission tomography (PET), and magnetic resonance spectroscopy (MRS) are the ideal methods for providing insight to these changes by measuring regional cerebral blood flow, glucose metabolism, and brain metabolite concentrations, respectively, after mild traumatic brain injury (mTBI). The purpose of this review is to provide an overview of the different methodologies and provide an up-to-date summary of recent findings with SPECT, PET, and MRS technologies, specifically after mTBI, as defined by standardized criteria. Given that the different physiological and pathological responses are heterogeneous, efforts will be made to separate studies at different time points after injury (acute, subacute, and chronic stages) as well as to the different types of mTBI such sports-related head injury where repetitive head injuries are much more common and may present a unique signature.

Keywords

Spectroscopy Single photon emission computed tomography Positron emission tomography Mild traumatic brain injury Metabolic imaging 

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • A. P. Lin
    • 1
  • H. J. Liao
    • 1
  • S. K. Merugumala
    • 1
  • S. P. Prabhu
    • 2
  • W. P. MeehanIII
    • 3
  • B. D. Ross
    • 1
    • 4
  1. 1.Department of RadiologyBrigham and Women’s Hospital, Harvard Medical SchoolBostonUSA
  2. 2.Advanced Image Analysis Lab, Department of Radiology, Children’s Hospital BostonHarvard Medical SchoolBostonUSA
  3. 3.Sports Concussion Clinic, Department of Medicine, Children’s Hospital BostonHarvard Medical SchoolBostonUSA
  4. 4.Huntington Medical Research InstitutesPasadenaUSA

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