Date: 04 Jun 2012
Brain regions associated with psychological pain: implications for a neural network and its relationship to physical pain
Research on brain areas involved in experiencing emotion and physical pain is abundant; however, psychological pain has received little attention in studies of the brain. The purpose of this systematic review was to provide an overview of studies on brain function related to psychological pain. The review was limited to studies in which participants experienced actual psychological pain or recalled a significant autobiographical event that may be assumed to have involved psychological pain. Based on results of the studies (N = 18), a tentative neural network for psychological pain is proposed that includes the thalamus, anterior and posterior cingulate cortex, the prefrontal cortex, cerebellum, and parahippocampal gyrus. Results indicated that grief may be a more accurate exemplar of psychological pain than recalled sadness, with indications of greater arousal during psychological pain. The proposed neural network for psychological pain overlaps to some extent with brain regions involved in physical pain, but results suggest a markedly reduced role for the insula, caudate, and putamen during psychological pain. Psychological pain is well known for its association with depression and as a precursor of suicidal behavior. Thus, identification of brain areas involved in psychological pain may help guide development of interventions to decrease mortality and morbidity.
Biro, D. (2010). Is there such a thing as psychological pain? and why It matters. Culture, Medicine and Psychiatry. doi:10.1007/s11013-010-9190-y.
Drevets, W. C., & Raichle, M. E. (1998). Reciprocal suppression of regional cerebral blood flow during emotional versus higher cognitive processes: implications for interactions between emotion and cognition. Cognition and Emotion. Special Issue: Neuropsychological perspectives on affective and anxiety disorders, 12(3), 353–385.
Eickhoff, S. B., Laird, A. R., Grefkes, C., Wang, L. E., Zilles, K., & Fox, P. T. (2009). Coordinate-based activation likelihood estimation meta-analysis of neuroimaging data: a random-effects approach based on empirical estimates of spatial uncertainty. Human Brain Mapping, 30(9), 2907–2926. doi:10.1002/hbm.20718.PubMedCrossRef
Friston, K. J., Holmes, A. P., Worsley, K. J., Poline, J. B., Frith, C. D., & Frackowiak, R. S. J. (1995). Statistical parametric maps in functional imaging: a general linear approach. Human Brain Mapping, 2(4), 189–210.CrossRef
Gerber, A. J., Posner, J., Gorman, D., Colibazzi, T., Yu, S., Wang, Z., et al. (2008). An affective circumplex model of neural systems subserving valence, arousal, and cognitive overlay during the appraisal of emotional faces. Neuropsychologia, 46(8), 2129–2139. doi:10.1016/j.neuropsychologia.2008.02.032.PubMedCrossRef
Hudson, A. J. (2000). Pain perception and response: central nervous system mechanisms. Canadian Journal of Neurological Sciences, 27(1), 2–16.PubMed
Keedwell, P. A., Andrew, C., Williams, S. C., Brammer, M. J., & Phillips, M. L. (2005). A double dissociation of ventromedial prefrontal cortical responses to sad and happy stimuli in depressed and healthy individuals. Biological Psychiatry, 58(6), 495–503. doi:10.1016/j.biopsych.2005.04.035.PubMedCrossRef
Lancaster, J. L., Rainey, L. H., Summerlin, J. L., Freitas, C. S., Fox, P. T., Evans, A. C., et al. (1997). Automated labeling of the human brain: a preliminary report on the development and evaluation of a forward-transform method. Human Brain Mapping, 5(4), 238–242. doi:10.1002/(SICI)1097-0193(1997)5:4<238::AID-HBM6>3.0.CO;2-4.PubMedCrossRef
Lancaster, J. L., Woldorff, M. G., Parsons, L. M., Liotti, M., Freitas, C. S., Rainey, L., et al. (2000). Automated Talairach atlas labels for functional brain mapping. Human Brain Mapping, 10(3), 120–131. doi:10.1002/1097-0193(200007)10:3<120::AID-HBM30>3.0.CO;2-8.PubMedCrossRef
Lane, R. D., Reiman, E. M., Ahern, G. L., Schwartz, G. E., & Davidson, R. J. (1997). Neuroanatomical correlates of happiness, sadness, and disgust. The American Journal of Psychiatry, 154(7), 926–933.PubMed
Martin, M. (1990). On the induction of mood. Clinical Psychology Review, 10(6), 669–697.CrossRef
Meerwijk, E. L., & Weiss, S. J. (2011). Toward a unifying definition of psychological pain. Journal of Loss & Trauma, 16(5), 402–412, doi:10.1080/15325024.2011.572044.
Munro, B. H. (2005). Statistical methods for health care research (5th ed.). Philadelphia, PA: Lippincott Williams & Wilkins.
Murray, H. A. (2008). Explorations in personality (70th ed.). New York, NY: Oxford University Press.
Orbach, I., Mikulincer, M., Gilboa-Schechtman, E., & Sirota, P. (2003). Mental pain and its relationship to suicidality and life meaning. Suicide & Life-Threatening Behavior, 33(3), 231–241.CrossRef
Orbach, I., Mikulincer, M., Sirota, P., & Gilboa-Schechtman, E. (2003). Mental pain: a multidimensional operationalization and definition. Suicide & Life-Threatening Behavior, 33(3), 219–230.CrossRef
Pardo, J. V., Pardo, P. J., & Raichle, M. E. (1993). Neural correlates of self-induced dysphoria. The American Journal of Psychiatry, 150(5), 713–719.PubMed
Pelletier, M., Bouthillier, A., Levesque, J., Carrier, S., Breault, C., Paquette, V., et al. (2003). Separate neural circuits for primary emotions? Brain activity during self-induced sadness and happiness in professional actors. Neuroreport, 14(8), 1111–1116. doi:10.1097/01.wnr.0000075421.59944.69.PubMedCrossRef
Pompili, M., Lester, D., Leenaars, A. A., Tatarelli, R., & Girardi, P. (2008). Psychache and suicide: a preliminary investigation. Suicide & Life-Threatening Behavior, 38(1), 116–121.CrossRef
Reisch, T., Seifritz, E., Esposito, F., Wiest, R., Valach, L., & Michel, K. (2010). An fMRI study on mental pain and suicidal behavior. Journal of Affective Disorders. doi:10.1016/j.jad.2010.03.005.
Sherwood, L. (2010). Human physiology: from cells to systems (7th ed.). Belmont, CA: Cengage Learning.
Shneidman, E. S. (1998). Perspectives on suicidology: further reflections on suicide and psychache. Suicide & Life-Threatening Behavior, 28(3), 245–250.
Soumani, A., Damigos, D., Oulis, P., Masdrakis, V., Ploumpidis, D., Mavreas, V., et al. (2011). Mental pain and suicide risk: application of the greek version of the Mental Pain and the Tolerance of Mental Pain scale. Psychiatriki, 22(4), 330–340.PubMed
Talairach, J., & Tournoux, P. (1988). Co-planar stereotaxic atlas of the human brain. 3-dimensional proportional system: an approach to cerebral imaging. New York: Thieme. Thieme Classics.
Tanida, M., Sakatani, K., Takano, R., & Tagai, K. (2004). Relation between asymmetry of prefrontal cortex activities and the autonomic nervous system during a mental arithmetic task: near infrared spectroscopy study. Neuroscience Letters, 369(1), 69–74. doi:10.1016/j.neulet.2004.07.076.PubMedCrossRef
van Heeringen, K., Van den Abbeele, D., Vervaet, M., Soenen, L., & Audenaert, K. (2010). The functional neuroanatomy of mental pain in depression. Psychiatry Research. doi:10.1016/j.pscychresns.2009.07.011.
Zubieta, J. K., Ketter, T. A., Bueller, J. A., Xu, Y., Kilbourn, M. R., Young, E. A., et al. (2003). Regulation of human affective responses by anterior cingulate and limbic mu-opioid neurotransmission. Archives of General Psychiatry, 60(11), 1145–1153. doi:10.1001/archpsyc.60.11.1145.PubMedCrossRef
- Brain regions associated with psychological pain: implications for a neural network and its relationship to physical pain
Brain Imaging and Behavior
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