Brain Imaging and Behavior

, Volume 3, Issue 2, pp 154–166

Characterization of Atrophic Changes in the Cerebral Cortex Using Fractal Dimensional Analysis

  • Richard D. King
  • Anuh T. George
  • Tina Jeon
  • Linda S. Hynan
  • Teddy S. Youn
  • David N. Kennedy
  • Bradford Dickerson
  • and the Alzheimer’s Disease Neuroimaging Initiative
Article

DOI: 10.1007/s11682-008-9057-9

Cite this article as:
King, R.D., George, A.T., Jeon, T. et al. Brain Imaging and Behavior (2009) 3: 154. doi:10.1007/s11682-008-9057-9

Abstract

The purpose of this project is to apply a modified fractal analysis technique to high-resolution T1 weighted magnetic resonance images in order to quantify the alterations in the shape of the cerebral cortex that occur in patients with Alzheimer’s disease. Images were selected from the Alzheimer’s Disease Neuroimaging Initiative database (Control N = 15, Mild-Moderate AD N = 15). The images were segmented using a semi-automated analysis program. Four coronal and three axial profiles of the cerebral cortical ribbon were created. The fractal dimensions (Df) of the cortical ribbons were then computed using a box-counting algorithm. The mean Df of the cortical ribbons from AD patients were lower than age-matched controls on six of seven profiles. The fractal measure has regional variability which reflects local differences in brain structure. Fractal dimension is complementary to volumetric measures and may assist in identifying disease state or disease progression.

Keywords

Fractal dimension Alzheimer’s disease Neuroimaging initiative Cerebral cortex Fractal analysis 

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Richard D. King
    • 1
    • 2
  • Anuh T. George
    • 1
    • 2
  • Tina Jeon
    • 1
    • 2
  • Linda S. Hynan
    • 3
    • 4
  • Teddy S. Youn
    • 1
  • David N. Kennedy
    • 5
  • Bradford Dickerson
    • 6
  • and the Alzheimer’s Disease Neuroimaging Initiative
  1. 1.Department of NeurologyUniversity of Texas Southwestern Medical CenterDallasUSA
  2. 2.Center for BrainHealthUniversity of Texas at DallasDallasUSA
  3. 3.Department of Clinical Sciences, Division of BiostatisticsUniversity of Texas Southwestern Medical CenterDallasUSA
  4. 4.Department of PsychiatryUniversity of Texas Southwestern Medical CenterDallasUSA
  5. 5.Center for Morphometric Analysis, Massachusetts General HospitalHarvard Medical SchoolBostonUSA
  6. 6.Department of Neurology, Massachusetts General HospitalHarvard Medical SchoolBostonUSA

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