Brain Imaging and Behavior

, Volume 3, Issue 2, pp 123–131

Stability of Default-Mode Network Activity in the Aging Brain

Article

DOI: 10.1007/s11682-008-9054-z

Cite this article as:
Beason-Held, L.L., Kraut, M.A. & Resnick, S.M. Brain Imaging and Behavior (2009) 3: 123. doi:10.1007/s11682-008-9054-z

Abstract

Activity attributed to the default-mode occurs during the resting state and is thought to represent self-referential and other intrinsic processes. Although activity in default-associated regions changes across the lifespan, little is known about the stability of default-mode activity in the healthy aging brain. We investigated changes in rest-specific activity across an 8 year period in older participants in the Baltimore Longitudinal Study of Aging (BLSA) neuroimaging study. Comparison of resting-state and recognition memory PET regional cerebral blood flow conditions from baseline and 8-year follow-up shows relative stability of rest-specific activity over time in medial frontal/anterior cingulate, hippocampal and posterior cingulate regions commonly associated with the default-mode. In contrast, prefrontal, parahippocampal and occipital cortical regions, which are not typically associated with default-mode activity, show changes over time. Overall, activity in the major components of the default-mode network remains stable in healthy older individuals, a finding which may assist in identifying factors that discriminate between normal and pathological aging.

Keywords

Functional imagingBrain functionActivationAgefMRIHumanDefault activity

Copyright information

© GovernmentEmployee 2008

Authors and Affiliations

  • L. L. Beason-Held
    • 1
    • 2
    • 3
  • M. A. Kraut
    • 2
  • S. M. Resnick
    • 1
  1. 1.Laboratory of Personality and Cognition, National Institute on AgingNIHBaltimoreUSA
  2. 2.Dept. of NeurologyJohns Hopkins University School of MedicineBaltimoreUSA
  3. 3.NIA/LPCBaltimoreUSA