Brain Imaging and Behavior

, Volume 2, Issue 3, pp 177–191

Gender Effects on HIV-Associated White Matter Alterations: A Voxel-Wise DTI Study

Authors

    • Rush University Medical Center
  • Glenn T. Stebbins
    • Rush University Medical Center
  • Russell E. Bartt
    • Rush University Medical Center
    • John H. Stroger, Jr. Hospital of Cook County
    • Ruth M. Rothstein CORE Center
  • Harold A. Kessler
    • Rush University Medical Center
    • John H. Stroger, Jr. Hospital of Cook County
    • Ruth M. Rothstein CORE Center
  • Oluwatoyin M. Adeyemi
    • Rush University Medical Center
    • John H. Stroger, Jr. Hospital of Cook County
    • Ruth M. Rothstein CORE Center
  • Eileen Martin
    • University of Illinois—Chicago
  • Roland Bammer
    • Stanford University
  • Michael E. Moseley
    • Stanford University
Article

DOI: 10.1007/s11682-008-9024-5

Cite this article as:
Smith, C.A., Stebbins, G.T., Bartt, R.E. et al. Brain Imaging and Behavior (2008) 2: 177. doi:10.1007/s11682-008-9024-5

Abstract

Sexual dimorphisms within the human brain are well-documented. Human immunodeficiency virus (HIV) infection is associated with atrophy and microstructural white matter alterations, yet sex-specific dimorphic brain alterations in persons living with HIV have not been systematically examined. To address this issue, we evaluated regional differences in normal-appearing white matter (NAWM) in adults with and without HIV utilizing diffusion tensor imaging. Through a voxel-by-voxel analytic approach, sexual dimorphisms in NAWM anisotropy and diffusivity were identified. In comparison to seronegative men and women, HIV infection contributed to a decline in the distribution of anisotropic differences between the sexes. Alterations in diffusivity were more complex, with seropositive women demonstrating an increase in regional diffusivity, while seropositive men demonstrated a reduction in regional differences. Sex by serostatus interactions within the left frontal lobe and bilateral thalamic region were identified. These results suggest that HIV contributes to sex-specific microstructural NAWM alterations, such that sex and serostatus differentially alter the integrity of the neuronal matrix.

Keywords

Diffusion tensor imagingNeuroimagingHIV/AIDSGender

Copyright information

© Springer Science+Business Media, LLC 2008