Polymorphism of DCDC2 Reveals Differences in Cortical Morphology of Healthy Individuals—A Preliminary Voxel Based Morphometry Study
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The purpose of this investigation was to determine whether there is an association between the putative reading disability (RD) susceptibility gene Doublecortin Domain Containing 2 (DCDC2), and gray matter (GM) distribution in the brain, in a sample of healthy control individuals.
Fifty-six control subjects were genotyped for an RD-associated deletion in intron 2 of DCDC2. Voxel based morphometry (VBM) was used to examine structural magnetic resonance imaging (MRI) scans to assess GM differences between the two groups.
Individuals heterozygous for the deletion exhibited significantly higher GM volumes in reading/language and symbol-decoding related brain regions including superior, medial and inferior temporal, fusiform, hippocampal/parahippocampal, inferior occipito-parietal, inferior and middle frontal gyri, especially in the left hemisphere. GM values correlated with published data on regional DCDC2 expression in a lateralized manner.
These data suggest a role for DCDC2 in GM distribution in language-related brain regions in healthy individuals.
- Polymorphism of DCDC2 Reveals Differences in Cortical Morphology of Healthy Individuals—A Preliminary Voxel Based Morphometry Study
Brain Imaging and Behavior
Volume 2, Issue 1 , pp 21-26
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- Structural imaging
- Author Affiliations
- 1. Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, 200 Retreat Ave., Hartford, CT, 06106, USA
- 2. Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
- 4. Department Neurobiology, Yale University School of Medicine, New Haven, CT, USA
- 8. VA CT Healthcare Center, West Haven, CT, USA
- 3. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA
- 5. Department of Pediatrics, Yale Child Health Research Center, Yale University School of Medicine, New Haven, CT, USA
- 6. The MIND Institute, Albuquerque, NM, USA
- 7. Department of ECE, University of New Mexico, Albuquerque, NM, USA