Chinese Journal of Cancer Research

, 11:218

Clinical significance of P-glycoprotein expression in breast cancer

Authors

  • Li En-xiao
    • Department of Medical Oncology, The First Clinical Medical CollegeXi'an Medical University
  • Li Rong
    • Department of Medical Oncology, The First Clinical Medical CollegeXi'an Medical University
  • Zhang Zhen-hua
    • Department of Medical Oncology, The First Clinical Medical CollegeXi'an Medical University
  • Wang Jian-bo
    • Department of Pathology, Xijing HospitalThe 4th Military Medical University
Clinical Observations

DOI: 10.1007/s11670-999-0017-8

Cite this article as:
En-xiao, L., Rong, L., Zhen-hua, Z. et al. Chin. J. Cancer Res. (1999) 11: 218. doi:10.1007/s11670-999-0017-8
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Abstract

Objective: to study the clinical significance of P-glycoprotein (P-gp) in breast cancer. Methods: Expression of P-gp in 60 cases of breast cancer was examined by immunohistochemistry. P-gp expression and response to chemotherapy were comparatively investigated in 19 patients with metastatic breast cancer. Results: The P-gp was positive in 48.3% of the 60 cases of breast cancer. P-gp expression was not related to patients' age, menstruation status, number of axillary lymph nodes involved, clinical stage, histological type, and hormonal receptor status (P>0.05). The frequency of metastasis (62.1%) and mortality (51.7%) were higher in P-gp positive cases than in negative cases (16.1% vs 12.9%, P<0.005). The 5-year survival rate of P-gp positive cases (48.3%) was significantly lower than that of negative cases (87.1%) (P<0.05). In patients who received adjuvant chemotherapy distant metastasis occurred more frequently in the P-gp positive cases (94.7%) than in the P-gp negative cases (57.1%) (P=0.0468). More P-gp negative patients (7/9) than positive patients (1/10) were responsive to chemotherapy (P=0.0055). Conclusion: Immunohistochemical examination of P-gp expression is useful in predicting response to chemotherapy and prognosis in breast cancer patients. P-gp positivity is associated with poor prognosis.

Key words

Breast cancerP-glycoproteinImmunohistochemistryPrognosis

Copyright information

© Editorial Board of Chinese Journal of Cancer Research 1999