Anti-tumor action and clinical application of proteasome inhibitor
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- Zhou, Ym., Yu, Mx., Long, H. et al. Chin. J. Cancer Res. (2008) 20: 77. doi:10.1007/s11670-008-0077-1
Ubiquitin-proteasome pathway mediates the degradation of cell protein, and cell cycle, gene translation and expression, antigen presentation and inflammatory development. Proteasome inhibitor can inhibit growth and proliferation of tumor cell, induce apoptosis and reverse multipledrug resistance of tumor cell, increase the sensitivity of other chemotherapeutic drugs and radiotherapy, and is a novel class of potent anti-tumor agents.