, Volume 20, Issue 2, pp 77-84

Anti-tumor action and clinical application of proteasome inhibitor

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Abstract

Ubiquitin-proteasome pathway mediates the degradation of cell protein, and cell cycle, gene translation and expression, antigen presentation and inflammatory development. Proteasome inhibitor can inhibit growth and proliferation of tumor cell, induce apoptosis and reverse multipledrug resistance of tumor cell, increase the sensitivity of other chemotherapeutic drugs and radiotherapy, and is a novel class of potent anti-tumor agents.

This work was supported by the National Outstanding Youth Scientists Foundation of china (No. 30225038) and the Youth and Middle-Age Scientists Science and Research Found of the Affiliated Hospital, Wuhan University of Science and Technology.