Chinese Journal of Cancer Research

, Volume 17, Issue 4, pp 294–297

Cytomegalovirus interstitial pneumonitis following allogeneic peripheral blood stem cell transplantation

  • Xu Xiao-hua 
  • Huang Lian-sheng 
  • Zhang Xiao-hong 
  • Zhu Kang-er 
  • Xu Yang 
  • Wu Dong 
  • Zhao Xiao-ying 
Articles

DOI: 10.1007/s11670-005-0030-5

Cite this article as:
Xu, X., Huang, L., Zhang, X. et al. Chin. J. Cancer Res. (2005) 17: 294. doi:10.1007/s11670-005-0030-5
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Abstract

Objective: To explore the risk factors and prophylaxis and treatment of cytomegalovirus interstitial pneumonitis (CMV-IP) after allogeneic peripheral blood stem cell transplantation (allo-PBSCT). Methods: 43 patients who received allo-PBSCT were allocated to either a Gancyclovir(GCV)-prophylaxis group (n=19) or a non-GCV prophylaxis group (n=24). A comparison was made of the incidence of CMV-IP in patients given or not given prophylactic gancyclovir. Results: 9 patients in non-GCV prophylaxis group developed late CMV-IP (P<0.05). Graft-versus-host-disease (GVHD) may be associated with a high risk of CMV-IP. 5 cases of CMV-IP were successfully treated with GCV, but 3 cases died of CMV-IP. The most common adverse event of GCV was neutropenia, but was reversible. Conclusion: CMV infection was a major cause of interstitial pneumonitis after allo-PBSCT, which correlated strongly with the severity of GVHD. Gancyclovir was shown to be effective in both prophylaxis and treatment of CMV-IP.

Key words

AllogeneicPeripheral blood stem cell transplantationInterstitial pneumonitisCytomegalovirusGraft-Versus-Host-Disease

CLC number

R730.5

Copyright information

© Chinese Journal 2005

Authors and Affiliations

  • Xu Xiao-hua 
    • 1
  • Huang Lian-sheng 
    • 1
  • Zhang Xiao-hong 
    • 1
  • Zhu Kang-er 
    • 1
  • Xu Yang 
    • 1
  • Wu Dong 
    • 1
  • Zhao Xiao-ying 
    • 1
  1. 1.Department of HematologySecond Hospital of Zhejiang UniversityHangzhou