Original Article

Chinese Journal of Integrative Medicine

, Volume 15, Issue 5, pp 328-332

First online:

Effect of Shenshao Tablet (参芍片) on the quality of life for coronary heart disease patients with stable angina pectoris

  • Jie Wang王 阶Affiliated withGuang’anmen Hospital, China Academy of Chinese Medical Sciences
  • , Qing-yong He何庆勇Affiliated withDongfang Hospital, Beijing University of Chinese Medicine Email author 
  • , Yun-ling Zhang张允岭Affiliated withDongfang Hospital, Beijing University of Chinese Medicine

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Abstract

Objective

To observe the effect of Chinese medicine Shenshao Tablet (参芍片, SST) on the: quality of life in coronary heart disease (CHD) patients with stable angina pectoris (SAP).

Methods

Sixty-six: patients with SAP confirmed by coronary angiography were enrolled and assigned to two groups by means of PROC PLAN using a SAS 6.12 software in a double-blinded, randomized, placebo-controlled design. Patients in the treated group were treated with SST, and the others in the control group were given placebo. The weekly angina frequency, quality of life scale [Seattle Angina Questionnaire (SAQ)] and incidence of important clinical events were observed to evaluate the intervention effect of SST on the quality of life for CHD patients with SAP.

Results

During the study, one case dropped out in the treated group and two cases in the control group,: respectively, and 63 cases including 32 cases in the treated group, and 31 cases in the control group completed the trial. After four weeks of treatment, the weekly angina frequency of the treated group (5.32±2.46 times per week) was significantly less than that of the control group (7.32±3.20 times per week, P<0.05). The total score of the quality of life in the treated group (71.30±5.44) was obviously higher than that in the control group (63.50±4.60, P<0.01), and the angina stability, angina frequency, and treatment satisfaction were significantly superior to those in the control group (P<0.01). The incidence of important clinical events of the treated group (3.1%) was lower than that of the control group (6.5%) during the six-month follow-up period, but the difference was insignificant (P>0.05).

Conclusion

SST could lower the angina frequency and greatly improve the quality of: life in CHD patients with SAP.

Key Words

Shenshao Tablet stable angina pectoris Seattle Angina Questionnaire important clinical events