Original Article

Chinese Journal of Integrative Medicine

, Volume 15, Issue 1, pp 19-25

Effect of Chinese drugs for supplementing qi, Nourishing Yin and activating blood circulation on myocardial perfusion in patients with acute myocardial infarction after revascularization

  • Yong-qiang Li李永强Affiliated withCardiovascular Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences
  • , Mei Jin金 枚Affiliated withDepartment of Internal Cardiac Medicine, Beijing Hospital of Traditional Chinese Medicine Affiliated to the Capital Medical University
  • , Sheng-lei Qiu仇盛蕾Affiliated withDepartment of Internal Cardiac Medicine, Beijing Hospital of Traditional Chinese Medicine Affiliated to the Capital Medical University
  • , Pei-li Wang王培利Affiliated withCardiovascular Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences
  • , Tian-gang Zhu朱天刚Affiliated withDepartment of Internal Cardiac Medicine, the People’s Hospital of Peking University
  • , Cheng-long Wang王承龙Affiliated withCardiovascular Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences
  • , Tian-chang Li李田昌Affiliated withDepartment of Internal Cardiac Medicine, Tongren Hospital Affiliated to the Capital Medical University
  • , Hong-xu Liu刘红旭Affiliated withDepartment of Internal Cardiac Medicine, Beijing Hospital of Traditional Chinese Medicine Affiliated to the Capital Medical University
  • , Hong Bian边 红Affiliated withDepartment of Internal Cardiac Medicine, Tongren Hospital Affiliated to the Capital Medical University
    • , Li-fang Yao姚立芳Affiliated withCardiovascular Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences
    • , Da-zhuo Shi史大卓Affiliated withCardiovascular Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences Email author 

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Abstract

Objective

To observe the effects of Chinese drugs for supplementing qi, nourishing yin and activating blood circulation on the myocardial perfusion in acute myocardial infarction (AMI) patients after revascularization.

Methods

Eighty patients with anterior or inferior ventricular wall AMI, who had received revascularization by intravenous thrombolysis or coronary bypass, were randomized into the treated group and the control group equally, both treated with conventional Western medical treatment, but combined, respectively, with Xinyue Capsule (心悦胶囊, XYC) plus Composite Salvia Tablet (CST) and placebo for 3 months. Dobutamine stress echocardiography (DSE) was performed 14 days and 3 months after revascularization, respectively on every patient to observe blood perfusion extent (b value), myocardial perfusion velocity (k value) and local blood fl ow volume (k × b) in left ventricular infarction-related vascular segments under stressed state.

Results

With 5 cases dropping out in the observation period (3 in the treated group and 2 in the control group), the trial was completed in 75 patients in total. The 14-day DSE shows that the b value and k × b value of left anterior ventricular wall mid segment and apex segment, and the k value of apex segment in patients with anterior wall AMI, as well as the b value and k × b of basal segment in patients with inferior wall AMI in the treated group were significantly higher than those in the control group (P<0.05 or P<0.01). The 3-month DSE shows that the b value of apex segment, k × b value of basal segment, mid segment and apex segment of left anterior ventricular wall in patients with anterior wall AMI as well as the b value and k × b value of basal segment of left inferior ventricular wall in patients with inferior wall AMI were all higher in the treated group than those in the control group, respectively (P<0.05). The comparison between 14-day DSE and 3-month DSE in the treated group showed that the b value of apex segment of left anterior ventricular wall in patients with anterior wall AMI and the k × b value of apex segment and mid segment of left inferior ventricular wall in patients with inferior wall AMI significantly increased along with the on-going treatment (P<0.05).

Conclusion

Therapy with Chinese drugs for supplementing qi, nourishing yin and activating blood circulation in combination with conventional Western medical treatment could obviously improve the blood perfusion at the myocardial tissue level in infarction-related vascular segments.

Key Words

Chinese drugs for supplementing qi nourishing yin and activating blood circulation acute myocardial infarction blood circulation rebuilding myocardial perfusion Doppler’s ultrasonic acoustic photography