Effect of Shengmai Injection (生脉注射液) on cardiac function and inflammatory reaction in patients with acute coronary syndrome
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
To confirm the effect of Shengmai Injection (生脉注射液, SMI) in improving cardiac function in patients with acute coronary syndrome (ACS) and to explore its influence on inflammatory reaction in patients.
Ninety ACS patients were randomized into two groups, the control group treated with conventional therapy and the SMI group treated with SMI. The patients’ cardiac function was noted and the content of high sensitive C-reactive protein (hs-CRP) in venous blood was measured before treatment and 1 week and 3 weeks after treatment, so as to observe and compare their changes between the two groups.
The cardiac output, stroke volume and ejection fraction in the SMI group after 3 weeks of treatment were all higher than those in the control group (P<0.05). The serum content of hs-CRP was reduced in both groups (P<0.05), but the reduction in the SMI group was more significant than that in the control group (P<0.05).
SMI could improve the cardiac function and further inhibit the inflammatory reaction in patients with ACS.
- Biasucci LM, Liuzzo G, Grillo RL, et al. Elevated levels of C-reactive protein at discharge in patients with unstable angina predict recurrent instability. Circulation 1999;99:855–860.
- Libbyb P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation 2002;105:1135–1143. CrossRef
- Ross R. Atherosclerosis-an inflammation disease. N Engl J Med 1999 14;340:115–126. CrossRef
- Anwar A, Zahid AA, Scheidegger KJ, et al. Tumor necrosis factor-alpha regulates insulin-like growth factor binding protein-3 expression in vascular smooth muscle. Circulation 2002;105:1220–1225. CrossRef
- van der Wal AC, Becker AE, van der Loos CM, et al. Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. Circulation 1994;89:36–44.
- Zhang YC, Chen RM, Zhao MH, et al. Effect of Shengmai Injection (生脉注射液) on hemodynamics in patients with dilated cardiomyopathy. Chin J Integr Tradit West Med (Chin) 2002;22(4):277–279.
- Chen YM, Yang JX, Xu JM, et al. Effect of Sheng-mai-san Injection vs Astragalus membranaceus Injection in treating coronary heart disease with left ventricular dysfunction. Chin J New Drugs Clin Remedie (Chin) 1998;17 (3):154–156.
- Lendon CL, Davies MJ, Born GV, et al. Atherosclerotic plaque caps are locally weakened when macrophages density is increased. Atherosclerosis 1991;87:87–90. CrossRef
- Biasucci LM, D’Onofrio G, Liuzzo G, et al. Intracellular neutrophil myeloperoxidase is reduced in unstable angina and acute myocardial infarction, but its reduction is not related to ischemia. J Am Coll Cardiol 1996;27:611–616. CrossRef
- Liuzzo G, Biasucci LM, Gallimore JR, et al. The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina. N Engl J Med 1994;331:417–424. CrossRef
- Lu BJ, Rong YZ, Zhao MH, et al. Effect of Shengmaisan (生脉散) on lipid peroxidation damage in acute myocardial infarction patients. Chin J Integr Tradit West Med (Engl) 1996;2(4):249–251.
- Effect of Shengmai Injection (生脉注射液) on cardiac function and inflammatory reaction in patients with acute coronary syndrome
Chinese Journal of Integrative Medicine
Volume 14, Issue 2 , pp 107-110
- Cover Date
- Print ISSN
- Online ISSN
- Chinese Association of Traditional and Western Medicine
- Additional Links
- Shengmai Injection
- acute coronary syndrome
- C-reactive protein
- inflammatory reaction
- cardiac function
- Industry Sectors
- Author Affiliations
- 1. Department of Internal Cardiology, Xinhua Hospital Affiliated to Shanghai Jiaotong Medical University School of Medicine, Shanghai, 200092, China
- 2. Department of Laboratory, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China