Trichomes + roots + ROS = artemisinin: regulating artemisinin biosynthesis in Artemisia annua L.
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Artemisinin is a highly effective sesquiterpene lactone therapeutic produced in the plant, Artemisia annua. Despite its efficacy against malaria and many other infectious diseases and neoplasms, the drug is in short supply mainly because the plant produces low levels of the compound. This review updates the current understanding of artemisinin biosynthesis with a special focus on the emerging knowledge of how biosynthesis of the compound is regulated in planta.
- Trichomes + roots + ROS = artemisinin: regulating artemisinin biosynthesis in Artemisia annua L.
In Vitro Cellular & Developmental Biology - Plant
Volume 47, Issue 3 , pp 329-338
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- Reactive oxygen species
- Jasmonic acid
- Salicylic acid
- Abscisic acid
- Gibberellic acid
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- Author Affiliations
- 1. Department of Biology and Biotechnology at Gateway, Worcester Polytechnic Institute, 100 Institute Rd, Worcester, MA, 01609, USA
- 2. Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical School, Philadelphia, PA, 19104, USA