In Vitro Cellular & Developmental Biology - Plant

, Volume 47, Issue 3, pp 329–338

Trichomes + roots + ROS = artemisinin: regulating artemisinin biosynthesis in Artemisia annua L.

Authors

  • Khanhvan T. Nguyen
    • Department of Biology and Biotechnology at GatewayWorcester Polytechnic Institute
  • Patrick R. Arsenault
    • Department of Biology and Biotechnology at GatewayWorcester Polytechnic Institute
    • Department of Pathology and Laboratory MedicineUniversity of Pennsylvania Medical School
    • Department of Biology and Biotechnology at GatewayWorcester Polytechnic Institute
Invited Review

DOI: 10.1007/s11627-011-9343-x

Cite this article as:
Nguyen, K.T., Arsenault, P.R. & Weathers, P.J. In Vitro Cell.Dev.Biol.-Plant (2011) 47: 329. doi:10.1007/s11627-011-9343-x

Abstract

Artemisinin is a highly effective sesquiterpene lactone therapeutic produced in the plant, Artemisia annua. Despite its efficacy against malaria and many other infectious diseases and neoplasms, the drug is in short supply mainly because the plant produces low levels of the compound. This review updates the current understanding of artemisinin biosynthesis with a special focus on the emerging knowledge of how biosynthesis of the compound is regulated in planta.

Keywords

ArtemisininTrichomeROSReactive oxygen speciesJasmonic acidSalicylic acidAbscisic acidGibberellic acidCytokinin

Copyright information

© The Society for In Vitro Biology 2011