Journal of General Internal Medicine

, Volume 28, Issue 11, pp 1525–1529

Putting the Pieces Together: Necrolytic Migratory Erythema and the Glucagonoma Syndrome

Authors

    • Division of Hospital Medicine, Department of MedicineOregon Health & Science University
  • Erin Gilbert
    • Department of SurgeryOregon Health & Science University
  • R. Samuel Hopkins
    • Department of DermatologyOregon Health & Science University
  • Helen Liu
    • Department of DermatologyOregon Health & Science University
  • Charles Lopez
    • Knight Cancer InstituteOregon Health & Science University
  • Michael Chu
    • Division of Endocrinology, Diabetes and Clinical Nutrition, Department of MedicineOregon Health & Science University
  • Marie Martin
    • Oregon Health & Science University
  • Brett Sheppard
    • Department of SurgeryOregon Health & Science University
Clinical Practice: Clinical Vignettes

DOI: 10.1007/s11606-013-2490-5

Cite this article as:
Halvorson, S.A.C., Gilbert, E., Hopkins, R.S. et al. J GEN INTERN MED (2013) 28: 1525. doi:10.1007/s11606-013-2490-5

Abstract

Glucagonomas are slow-growing, rare pancreatic neuroendocrine tumors. They may present with paraneoplastic phenomena known together as the “glucagonoma syndrome.” A hallmark sign of this syndrome is a rash known as necrolytic migratory erythema (NME). In this paper, the authors describe a patient with NME and other features of the glucagonoma syndrome. The diagnosis of this rare tumor requires an elevated serum glucagon level and imaging confirming a pancreatic tumor. Surgical and medical treatment options are reviewed. When detected early, a glucagonoma is surgically curable. It is therefore imperative that clinicians recognize the glucagonoma syndrome in order to make an accurate diagnosis and refer for treatment.

KEY WORDS

glucagonomaneuroendocrine tumorsnecrolytic migratory erythema

Copyright information

© Society of General Internal Medicine 2013