Cost-Effectiveness of Long-Term Outpatient Buprenorphine-Naloxone Treatment for Opioid Dependence in Primary Care
- Bruce R. SchackmanAffiliated withDepartment of Public Health, Weill Cornell Medical College Email author
- , Jared A. LeffAffiliated withDepartment of Public Health, Weill Cornell Medical College
- , Daniel PolskyAffiliated withDivision of Internal Medicine, University of Pennsylvania School of Medicine
- , Brent A. MooreAffiliated withDepartment of Psychiatry, Yale University School of Medicine
- , David A. FiellinAffiliated withDepartment of Medicine, Yale University School of Medicine
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Primary care physicians with appropriate training may prescribe buprenorphine-naloxone (bup/nx) to treat opioid dependence in US office-based settings, where many patients prefer to be treated. Bup/nx is off patent but not available as a generic.
We evaluated the cost-effectiveness of long-term office-based bup/nx treatment for clinically stable opioid-dependent patients compared to no treatment.
DESIGN, SUBJECTS, AND INTERVENTION
A decision analytic model simulated a hypothetical cohort of clinically stable opioid-dependent individuals who have already completed 6 months of office-based bup/nx treatment. Data were from a published cohort study that collected treatment retention, opioid use, and costs for this population, and published quality-of-life weights. Uncertainties in estimated monthly costs and quality-of-life weights were evaluated in probabilistic sensitivity analyses, and the economic value of additional research to reduce these uncertainties was also evaluated.
Bup/nx, provider, and patient costs in 2010 US dollars, quality-adjusted life years (QALYs), and incremental cost-effectiveness (CE) ratios ($/QALY); costs and QALYs are discounted at 3% annually.
In the base case, office-based bup/nx for clinically stable patients has a CE ratio of $35,100/QALY compared to no treatment after 24 months, with 64% probability of being < $100,000/QALY in probabilistic sensitivity analysis. With a 50% bup/nx price reduction the CE ratio is $23,000/QALY with 69% probability of being < $100,000/QALY. Alternative quality-of-life weights result in CE ratios of $138,000/QALY and $90,600/QALY. The value of research to reduce quality-of-life uncertainties for 24-month results is $6,400 per person eligible for treatment at the current bup/nx price and $5,100 per person with a 50% bup/nx price reduction.
Office-based bup/nx for clinically stable patients may be a cost-effective alternative to no treatment at a threshold of $100,000/QALY depending on assumptions about quality-of-life weights. Additional research about quality-of-life benefits and broader health system and societal cost savings of bup/nx therapy is needed.
KEY WORDSbuprenorphine-naloxone primary health care cost-effectiveness opioid substitution therapy
- Cost-Effectiveness of Long-Term Outpatient Buprenorphine-Naloxone Treatment for Opioid Dependence in Primary Care
Journal of General Internal Medicine
Volume 27, Issue 6 , pp 669-676
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- primary health care
- opioid substitution therapy
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- Author Affiliations
- 1. Department of Public Health, Weill Cornell Medical College, 402 East 67th Street, New York, NY, 10065, USA
- 2. Division of Internal Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
- 3. Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
- 4. Department of Medicine, Yale University School of Medicine, New Haven, CT, USA