Journal of General Internal Medicine

, Volume 27, Issue 7, pp 861–867

Utilization of Hepatocellular Carcinoma Surveillance Among American Patients: A Systematic Review

  • Amit G. Singal
  • Adam Yopp
  • Celette S. Skinner
  • Milton Packer
  • William M. Lee
  • Jasmin A. Tiro
Reviews

DOI: 10.1007/s11606-011-1952-x

Cite this article as:
Singal, A.G., Yopp, A., S. Skinner, C. et al. J GEN INTERN MED (2012) 27: 861. doi:10.1007/s11606-011-1952-x

ABSTRACT

BACKGROUND

Although surveillance for hepatocellular carcinoma (HCC) is recommended in high-risk patients, several studies have suggested it is being underutilized in clinical practice. The aim of our study was to quantify utilization rates for HCC surveillance among patients with cirrhosis and summarize patterns of association between utilization rates and patient socio-demographic characteristics.

DATA SOURCES

We performed a systematic literature review using the Medline database from January 1990 through March 2011 and a manual search of national meeting abstracts from 2008–2010.

METHODS

Two investigators independently extracted data on patient populations, study methods, and results using standardized forms. A pooled surveillance rate with 95% confidence intervals was calculated. Pre-specified subgroup analysis was performed to find correlates of surveillance utilization.

RESULTS

We identified nine studies that met inclusion criteria. The pooled surveillance rate was 18.4% (95%CI 17.8%–19.0%). Surveillance rates were significantly higher among patients followed in subspecialty gastroenterology clinics compared to those followed in primary care clinics (51.7% vs. 16.9%, p < 0.001). Non-Caucasians and patients of low socioeconomic status had lower surveillance rates than their counterparts.

CONCLUSIONS

Utilization rates for HCC surveillance are low, although they are significantly higher among patients followed in subspecialty clinics. Current studies fail to determine why HCC surveillance is not being performed. Future efforts should focus on identifying appropriate intervention targets to increase surveillance rates and reduce socio-demographic disparities.

KEY WORDS

hepatocellular carcinomasurveillanceutilizationsocio-demographic disparitiesUnited States

Copyright information

© Society of General Internal Medicine 2011

Authors and Affiliations

  • Amit G. Singal
    • 1
    • 3
    • 4
  • Adam Yopp
    • 2
    • 4
  • Celette S. Skinner
    • 3
    • 4
  • Milton Packer
    • 3
  • William M. Lee
    • 1
  • Jasmin A. Tiro
    • 3
    • 4
  1. 1.Division of Gastroenterology, Department of Internal MedicineUT Southwestern Medical CenterDallasUSA
  2. 2.Department of SurgeryUniversity of Texas SouthwesternDallasUSA
  3. 3.Department of Clinical SciencesUniversity of Texas SouthwesternDallasUSA
  4. 4.Harold C. Simmons Cancer CenterUT Southwestern Medical CenterDallasUSA