Primary Non-adherence of Medications: lifting the veil on prescription-filling behaviors
Economists say that consumers “vote with their feet”. That is, in order to understand human behavior, we can interpret people's underlying preferences by observing their choices. Unfortunately, in much of the social sciences, researchers are limited in their ability to directly observe people’s choices. This is particularly true when studying the problem of medication adherence. Medication “adherence” is defined as the degree of patient compliance with providers’ recommendations about the daily timing, dosage, and frequency of medication use. This differs from “persistence,” which refers to whether patients continue a treatment for the prescribed duration. Both are difficult to study. Aside from watching patients drop pills into their mouths and swallow them every day (which is clearly infeasible except for extreme circumstances such as directly observed treatment for multidrug resistant tuberculosis or HIV) researchers are left to examine surrogate measures of adherence behaviors.
- Ho PM, Rumsfeld JS, Masoudi FA, et al. Effect of medication nonadherence on hospitalization and mortality among patients with diabetes mellitus. Arch Int Med. 2006;166:1836–41. CrossRef
- Simpson SH, Eurich DT, Majumdar SR, Padwal RS, Tsuyuki RT, Varney J, Johnson JA. A meta-analysis of the association between adherence to drug therapy and mortality. BMJ. 2006;332:15–9. CrossRef
- McCombs JS, Nichol MB, Newman CM, Sclar DA. The costs of interrupting antihypertensive drug therapy in a Medicaid population. Med Care. 1994;32(3):214–26. CrossRef
- Goldman DP, Joyce GF, Zheng Y. Prescription Drug Cost Sharing: Associations With Medication and Medical Utilization and Spending and Health. JAMA. 2007;298:61–9. CrossRef
- Safran DG, Neuman P, Schoen C, Kitchman MS, Wilson IB, Cooper B, Li A, Chang H, Rogers WH. Prescription Drug Coverage And Seniors: Findings From A 2003 National Survey. Health Aff. 2005 Jan-Jun;Suppl Web Exclusives:W5-152-W5-166.
- Natarajan S, Nietert PJ. National trends in screening, prevalence, and treatment of cardiovascular risk factors. Prev Med. 2003;36(4):389–97. CrossRef
- Solomon MD, Goldman DP, Joyce GF, Escarce JJ. Cost sharing and the initiation of drug therapy for the chronically ill. Arch Intern Med. 2009;169(8):740–8. CrossRef
- Gibson TB, Mark TL, McGuigan KA, Axelsen K, Wang S. The effects of prescription drug copayments on statin adherence. Am J Manag Care. 2006;12:509–17.
- Jackevicius CA, Li P, Tu JV. Prevalence, predictors, and outcomes of primary nonadherence after acute myocardial infarction. Circulation. 2008;117(8):1028–36. CrossRef
- Fischer MA, Stedman MR, Li J, Vogeli C, Shrank WH, Brookhart MA, Weissman JS. Primary medication non-adherence: analysis of 195,930 electronic prescriptions. J Gen Intern Med. 2010; XXXXXX\.
- Bell DS, Marken RS, Meili RC, Wang CJ, Rosen M, Brook RH. RAND Electronic Prescribing Expert Advisory Panel. Recommendations for comparing electronic prescribing systems: results of an expert consensus panel. Health Aff (Millwood). 2004 Jan-Jun;Suppl Web Exclusives:W4-305–17.
- Gandhi TK, Weingart SN, Seger AC, Borus J, Burdick E, Poon EG, Leape LL, Bates DW. Outpatient prescribing errors and the impact of computerized prescribing. J Gen Intern Med. 2005;20(9):837–41. CrossRef
- Primary Non-adherence of Medications: lifting the veil on prescription-filling behaviors
Journal of General Internal Medicine
Volume 25, Issue 4 , pp 280-281
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