Primary Medication Non-Adherence: Analysis of 195,930 Electronic Prescriptions
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Non-adherence to essential medications represents an important public health problem. Little is known about the frequency with which patients fail to fill prescriptions when new medications are started (“primary non-adherence”) or predictors of failure to fill.
Evaluate primary non-adherence in community-based practices and identify predictors of non-adherence.
75,589 patients treated by 1,217 prescribers in the first year of a community-based e-prescribing initiative.
We compiled all e-prescriptions written over a 12-month period and used filled claims to identify filled prescriptions. We calculated primary adherence and non-adherence rates for all e-prescriptions and for new medication starts and compared the rates across patient and medication characteristics. Using multivariable regressions analyses, we examined which characteristics were associated with non-adherence.
Primary medication non-adherence.
Of 195,930 e-prescriptions, 151,837 (78%) were filled. Of 82,245 e-prescriptions for new medications, 58,984 (72%) were filled. Primary adherence rates were higher for prescriptions written by primary care specialists, especially pediatricians (84%). Patients aged 18 and younger filled prescriptions at the highest rate (87%). In multivariate analyses, medication class was the strongest predictor of adherence, and non-adherence was common for newly prescribed medications treating chronic conditions such as hypertension (28.4%), hyperlipidemia (28.2%), and diabetes (31.4%).
Many e-prescriptions were not filled. Previous studies of medication non-adherence failed to capture these prescriptions. Efforts to increase primary adherence could dramatically improve the effectiveness of medication therapy. Interventions that target specific medication classes may be most effective.
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- Primary Medication Non-Adherence: Analysis of 195,930 Electronic Prescriptions
Journal of General Internal Medicine
Volume 25, Issue 4 , pp 284-290
- Cover Date
- Print ISSN
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- Additional Links
- electronic prescribing
- health information technology
- Industry Sectors
- Author Affiliations
- 1. Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital, 1620 Tremont Street, Suite 3030, Boston, MA, 02120, USA
- 2. Institute for Health Policy, Massachusetts General Hospital, Boston, MA, USA