Use of Aspirin Among Diabetics in the Primary Prevention of Cardiovascular Disease: Need For Reliable Randomized Evidence and Astute Clinical Judgment

  • Patricia R. Hebert
  • Wendy R. Schneider
  • Charles H. Hennekens

DOI: 10.1007/s11606-009-1095-5

Cite this article as:
Hebert, P.R., Schneider, W.R. & Hennekens, C.H. J GEN INTERN MED (2009) 24: 1248. doi:10.1007/s11606-009-1095-5



The American Heart Association Guidelines recommend aspirin for all apparently healthy individuals whose 10-year risk of a first coronary heart disease (CHD) event is >10%.


The United States (US) Preventive Services Task Force (USPSTF) has recently updated its guidelines to encourage men 45 to 79 years and women 55 to 79 years to use aspirin when the potential benefit outweighs the potential harm. In addition, in some US guidelines, diabetes is considered to be a CHD risk equivalent.


Two recently published trials, the Japanese Primary Prevention of Atherosclerosis with Aspirin for Diabetes (JPAD) and the Prevention of Progression of Arterial Disease and Diabetes (POPADAD), concluded that aspirin did not reduce risks of CHD. Both JPAD and POPADAD had inadequate statistical power. Reliable randomized evidence is necessary to provide a sufficient totality of evidence about benefits and risks among diabetics.


At present, astute individual clinical judgments are necessary.


diabetes cardiovascular disease prevention risk assessment evidenced-based medicine 

Copyright information

© Society of General Internal Medicine 2009

Authors and Affiliations

  • Patricia R. Hebert
    • 1
  • Wendy R. Schneider
    • 1
  • Charles H. Hennekens
    • 1
  1. 1.Florida Atlantic UniversityBoca RatonUSA

Personalised recommendations