Tea Consumption and Risk of Type 2 Diabetes: A Meta-Analysis of Cohort Studies
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Tea consumption has been extensively studied in relation to various diseases, several epidemiologic studies have been performed to investigate the association of tea consumption with type 2 diabetes; however, the results of these studies were not entirely consistent.
To conduct a meta-analysis of studies that assessed the association of tea consumption and the risk of type 2 diabetes.
RESEARCH DESIGN AND METHODS
We performed a systematic literature search through November 2008 in PUBMED, MEDLINE, EMBASE, and Cochrane Database of Systematic Reviews. The search was limited to English-language studies. Studies were excluded if they were type 1 diabetes, animal studies. Nine cohort studies were identified by two authors, and summary relative risks (RRs) were calculated using a random-effects model.
We identified nine cohort studies, including 324,141 participants and 11,400 incident cases of type 2 diabetes with follow-up ranging from 5 to 18 years. The summary adjusted RR did not show that tea consumption was associated with a reduced type 2 diabetes risk (RR, 0.96; 95% confidence interval (CI), 0.92–1.01). Evidence from the results of our stratified analyses revealed that tea consumption ≥4 cups per day (RR, 0.8; 95% CI, 0.7–0.93) might play a role in the prevention of type 2 diabetes. However, no statistically significant association was observed for sex and the follow-up durations stratified between tea consumption and type 2 diabetes.
This meta-analysis indicates that tea consumption ≥4 cups per day may lower the risk of type 2 diabetes.
- King H, Aubert RE, Herman WH. Global burden of diabetes, 1995–2025: prevalence, numerical estimates, and projections. Diabetes Care. 1998; 21: 1414–31. CrossRef
- Zimmet P. The burden of type 2 diabetes: are we doing enough. Diabetes Metab. 2003; 29: 6S9–18. CrossRef
- Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004; 27: 1047–53. CrossRef
- Hu FB, Manson JE, Stampfer MJ. Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. N Engl J Med. 2001; 345: 790–7. CrossRef
- Robertson R, Zhou H, Zhang T, Harmon JS. Chronic oxidative stress as a mechanism for glucose toxicity of the beta cell in type 2 diabetes. Cell Biochem Biophys. 2007; 48: 139–46. CrossRef
- Wright E Jr, Scism-Bacon JL, Glass LC. Oxidative stress in type 2 diabetes: the role of fasting and postprandial glycaemia. Int J Clin Pract. 2006; 60: 308–14. CrossRef
- Ceriello A, Motz E. Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited. Arterioscler Thromb Vasc Biol. 2004; 24: 816–23. CrossRef
- Dona M, Dell’Aica I, Calabrese F, et al. Neutrophil restraint by green tea: inhibition of inflammation, associated angiogenesis, and pulmonary fibrosis. J Immunol. 2003; 170: 4335–41.
- Osada K, Takahashi M, Hoshina S, Nakamura M, Nakamura S, Sugano M. Tea catechins inhibit cholesterol oxidation accompanying oxidation of low density lipoprotein in vitro. Comp Biochem Physiol Part C Toxicol Pharmacol. 2001; 128: 153–64. CrossRef
- Raederstorff DG, Schlachter MF, Elste V, Weber P. Effect of EGCG on lipid absorption and plasma lipid levels in rats. J Nutr Biochem. 2003; 14: 326–32. CrossRef
- McKay DL, Blumberg JB. The role of tea in human health: an update. J Am Coll Nutr. 2002; 21: 1–13.
- Cheng TO. All teas are not created equal the Chinese green tea and cardiovascular health. Int J Cardiol. 2006; 108: 301–8. CrossRef
- Blumberg J. Introduction to the proceedings of the third international scientific symposium on tea and human health: role of flavonoids in the diet. J Nutr. 2003; 133: 3244S–3246S.
- Graham HN. Green tea composition, consumption, and polyphenol chemistry. Prev Med. 1992; 21: 334–50. CrossRef
- Balentine DA, Wiseman SA, Bouwens LC. The chemistry of tea flavonoids. Crit Rev Food Sci Nutr. 1997; 37: 693–704. CrossRef
- Peters U, Poole C, Arab L. Does tea affect cardiovascular disease? A meta-analysis. Am J Epidemiol. 2001; 154: 495–503. CrossRef
- Sun CL, Yuan JM, Koh WP, Yu MC. Green tea, black tea and colorectal cancer risk: a meta-analysis of epidemiologic studies. Carcinogenesis. 2006; 27: 1301–9. CrossRef
- Nakachi K, Matsuyama S, Miyake S, Suganuma M, Imai K. Preventive effects of drinking green tea on cancer and cardiovascular disease: epidemiological evidence for multiple targeting prevention. BioFactors. 2000; 13: 49–54. CrossRef
- Sabu MC, Smitha K, Kuttan R. Anti-diabetic activity of green tea polyphenols and their role in reducing oxidative stress in experimental diabetes. J Ethnopharmacol. 2002; 83: 109–16. CrossRef
- Waltner-Law ME, Wang XL, Law BK, Hall RK, Nawano M, Granner DK. Epigallocatechin gallate, a constituent of green tea, represses hepatic glucose production. J Biol Chem. 2002; 277: 34933–40. CrossRef
- Anderson RA, Polansky MM. Tea enhances insulin activity. J Agric Food Chem. 2002; 50: 7182–6. CrossRef
- Venables MC, Hulston CJ, Cox HR, Jeukendrup AE. Green tea extract ingestion, fat oxidation, and glucose tolerance in healthy humans. Am J Clin Nutr. 2008; 87: 778–84.
- Wolfram S, Raederstorff D, Preller M. Epigallocatechin gallate supplementation alleviates diabetes in rodents. J Nutr. 2006; 136: 2512–8.
- Tsuneki H, Ishizuka M, Terasawa M, Wu JB, Sasaoka T, Kimura I. Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humans. BMC Pharmacology. 2004; 4: 18. CrossRef
- Polychronopoulos E, Zeimbekis A, Kastorini CM, Papairakleous N, Vlachou I, Bountziouka V, Panagiotakos DB. Effects of black and green tea consumption on blood glucose levels in non-obese elderly men and women from Mediterranean Islands (MEDIS epidemiological study). Eur J Nutr. 2008; 47: 10–6. CrossRef
- van Dam RM, Willett WC, Manson JE, Hu FB. Coffee, caffeine, and risk of type 2 diabetes: a prospective cohort study in younger and middle-aged U.S. women. Diabetes Care. 2006; 29: 398–403. CrossRef
- Salazar-Martinez E, Willett WC, Ascherio A, et al. Coffee consumption and risk for type 2 diabetes mellitus. Ann Intern Med. 2004; 140: 1–8.
- Greenberg JA, Axen KV, Schnoll R, Boozer CN. Coffee, tea and diabetes: the role of weight loss and caffeine. Int J Obes. 2005; 29: 1121–9. CrossRef
- Song Y, Manson JE, Buring JE, Sesso HD, Liu S. Associations of dietary flavonoids with risk of type 2 diabetes, and markers of insulin resistance and systemic inflammation in women: a prospective study and cross-sectional analysis. J Am Coll Nutr. 2005; 24: 376–84.
- Hu G, Jousilahti P, Peltonen M, Bidel S, Tuomilehto J. Joint association of coffee consumption and other factors to the risk of type 2 diabetes: a prospective study in Finland. Int J Obes (Lond). 2006; 30: 1742–9. CrossRef
- Hamer M, Witte DR, Mosdøl A, Marmot MG, Brunner EJ. Prospective study of coffee and tea consumption in relation to risk of type 2 diabetes mellitus among men and women: The Whitehall II study. Br J Nutr. 2008; 4: 1–8.
- Iso H, Date C, Wakai K, Fukui M, Tamakoshi A; JACC Study Group. The relationship between green tea and total caffeine intake and risk for self-reported type 2 diabetes among Japanese adults. Ann Intern Med. 2006;144:554–62.
- Pereira MA, Parker ED, Folsom AR. Coffee consumption and risk of type 2 diabetes mellitus: an 11-year prospective study of 28 812 postmenopausal women. Arch Intern Med. 2006; 166: 1311–6. CrossRef
- Odegaard AO, Pereira MA, Koh WP, Arakawa K, Lee HP, Yu MC. Coffee, tea, and incident type 2 diabetes: the Singapore Chinese Health Study. Am J Clin Nutr. 2008; 88: 979–85.
- Yamaji T, Mizoue T, Tabata S, et al. Coffee consumption and glucose tolerance status in middle-aged Japanese men. Diabetologia. 2004; 47: 2145–51. CrossRef
- MacKenzie T, Comi R, Sluss P, et al. Metabolic and hormonal effects of caffeine: randomized, double-blind, placebo-controlled crossover trial. Metabolism. 2007; 56: 1694–8. CrossRef
- Fukino Y, Shimbo M, Aoki N, Okubo T, Iso H. Randomized controlled trial for an effect of green tea consumption on insulin resistance and inflammation markers. J Nutr Sci Vitaminol. 2005; 51: 335–42.
- Hosoda K, Wang MF, Liao ML, et al. Antihyperglycemic effect of oolong tea in type 2 diabetes. Diabetes Care. 2003; 26: 1714–8. CrossRef
- Ryu OH, Lee J, Lee KW, et al. Effects of green tea consumption on inflammation, insulin resistance and pulse wave velocity in type 2 diabetes patients. Diabetes Res Clin Pract. 2006; 71: 356–8. CrossRef
- Mackenzie T, Leary L, Brooks WB. The effect of an extract of green and black tea on glucose control in adults with type 2 diabetes mellitus: double-blind randomized study. Metabolism. 2007; 56: 1340–4. CrossRef
- Nettleton JA, Harnack LJ, Scrafford CG, Mink PJ, Barraj LM, Jacobs DR Jr. Dietary flavonoids and flavonoid-rich foods are not associated with risk of type 2 diabetes in postmenopausal women. J Nutr. 2006; 136: 3039–45.
- Hodge AM, English DR, O’Dea K, Giles GG. Dietary patterns and diabetes incidence in the Melbourne Collaborative Cohort Study. Am J Epidemiol. 2007; 165: 603–10. CrossRef
- Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of observational studies in epidemiology (MOOSE) group. JAMA. 2000; 283: 2008–12. CrossRef
- Willi C, Bodenmann P, Ghali WA, Faris PD, Cornuz J. Active smoking and the risk of type 2 diabetes: a systematic review and meta-analysis. JAMA. 2007; 298: 2654–64. CrossRef
- DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986; 7: 177–88. CrossRef
- Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002; 21: 1539–58. CrossRef
- Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997; 315: 629–34.
- Babu PV, Sabitha KE, Shyamaladevi CS. Therapeutic effect of green tea extract on oxidative stress in aorta and heart of streptozotocin diabetic rats. Chem Biol Interact. 2006; 162: 114–20. CrossRef
- Wu LY, Juan CC, Hwang LS, Hsu YP, Ho PH, Ho LT. Green tea supplementation ameliorates insulin resistance and increases glucose transporter IV in a fructose-fed rat model. Eur J Nutr. 2004; 43: 116–24. CrossRef
- Wu LY, Juan CC, Ho LT, Hsu YP, Hwang LS. Effect of green tea supplementation on insulin sensitivity in Sprague-Dawley rats. J Agric Food Chem. 2004; 52: 643–8. CrossRef
- Islam MS, Choi H. Green tea, anti-diabetic or diabetogenic: a dose response study. BioFactors. 2007; 29: 45–53. CrossRef
- Chen R. Green tea, coffee, and diabetes. Ann Intern Med. 2006; 145: 633.
- Chen R, Wei L, Hu Z, Qin X, Copeland JR, Hemingway H. Depression in older people in rural China. Arch Intern Med. 2005; 165: 2019–25. CrossRef
- Knol MJ, Twisk JW, Beekman AT, Heine RJ, Snoek FJ, Pouwer F. Depression as a risk factor for the onset of type 2 diabetes mellitus. A meta-analysis. Diabetologia. 2006; 49: 837–45. CrossRef
- Tea Consumption and Risk of Type 2 Diabetes: A Meta-Analysis of Cohort Studies
Journal of General Internal Medicine
Volume 24, Issue 5 , pp 557-562
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- type 2 diabetes
- Industry Sectors
- Author Affiliations
- 1. Department of Endocrinology, Drum Tower Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu Province, China
- 2. Department of Endocrinology, Affiliated Drum Tower Hospital, Medical College of Nanjing University, Nanjing, Jiangsu Province, China