Body Mass Index is Inversely Related to Mortality in Elderly Subjects
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- Weiss, A., Beloosesky, Y., Boaz, M. et al. J GEN INTERN MED (2008) 23: 19. doi:10.1007/s11606-007-0429-4
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To study the long-term effect of being overweight on mortality in very elderly subjects.
The medical records of 470 inpatients (226 males) with a mean age of 81.5 ± 7 years and hospitalized in an acute geriatric ward between 1999 and 2000 were reviewed for this study. Body mass index (BMI) at admission day was subdivided into quartiles: <22, 22–25, 25.01–28, and ≥28 kg/m2. Patients were followed-up until August 31, 2004. Mortality data were taken from death certificates.
During a mean follow-up of 3.46 ± 1.87 years (median 4.2 years [range 1.6 to 5.34 years]), 248 patients died. Those who died had lower baseline BMI than those who survived (24.1 ± 4.2 vs 26.3 ± 4.6 kg/m2; p < .0001). The age-adjusted mortality rate decreased from 24 to 9.6 per 100 patient-years from the highest to lowest BMI quartile (p < .001). BMI was associated with all-cause and cause-specific mortality even after controlling for sex. A multivariate Cox proportional hazards model identified that even after controlling for male gender, age, renal failure, and diabetes mellitus, which increased the risk of all-cause mortality, elevated BMI decreased the all-cause mortality risk.
In very elderly subjects, elevated BMI was associated with reduced mortality risk.
KEY WORDSelderly body mass index mortality
body mass index
millimeter Hg (mercury)
ischemic heart disease
congestive heart failure
- EHF = Ĥ0(t)
empirical cumulative hazards function
systolic blood pressure
diastolic blood pressure
angiotensin converting enzyme
beats per minute