Journal of General Internal Medicine

, Volume 22, Issue 11, pp 1560–1565

Geographic Variation in Chronic Obstructive Pulmonary Disease Exacerbation Rates

Original Article

DOI: 10.1007/s11606-007-0354-6

Cite this article as:
Joo, M.J., Lee, T.A. & Weiss, K.B. J GEN INTERN MED (2007) 22: 1560. doi:10.1007/s11606-007-0354-6



Exacerbations are important disease events for patients with chronic obstructive pulmonary disease (COPD) as they are relatively frequent, result in significant resource use and can indicate worsening disease. Little is known about variation in COPD exacerbation rates across a health system in various geographic regions.


To compare COPD exacerbation rates by regional service networks called Veterans Integrated Service Network (VISN) in the Veterans Health Administration (VA) system.


Retrospective, observational study.


Patients with a COPD diagnosis from October 1999 to September 2000 with follow-up to September 2002.


Acute exacerbations of COPD during the baseline and follow-up periods.


A total of 198,981 patients were identified. Average exacerbation rate at baseline was 0.503 events per person per year. In the follow-up period, there were 187,686 exacerbations experienced by 87,494 persons (44.0% of cohort). During follow-up, the average adjusted exacerbation rate was 0.589 per person per year and varied from 0.335 (95% CI, 0.328–0.342) in VISN 1 to 0.749 (95% CI, 0.735–0.0.763) in VISN 9. Using the median rate of exacerbation during the baseline period as the referent, 9 VISNs had lower adjusted rate ratios and 12 VISNs had higher adjusted rate ratios in the follow-up period.


Geographic variation in the VA VISN system supports evidence that the medical care system including provider factors, and less so patient factors, affect COPD exacerbations. Understanding the reasons underlying this variation in COPD exacerbation rates may lead to improvements in future care and outcomes.


COPDexacerbationgeographic variationoutcomes

Copyright information

© Society of General Internal Medicine 2007

Authors and Affiliations

  • Min J. Joo
    • 1
    • 2
    • 4
  • Todd A. Lee
    • 1
    • 2
    • 3
  • Kevin B. Weiss
    • 1
    • 2
    • 3
  1. 1.Center for Management of Complex Chronic CareHines VA HospitalHinesUSA
  2. 2.Institute for Healthcare StudiesNorthwestern University Feinberg School of MedicineChicagoUSA
  3. 3.Division of General Internal Medicine, Department of MedicineNorthwestern University Feinberg School of MedicineChicagoUSA
  4. 4.University of IllinoisChicagoUSA